Impact of Six-week Viral Load on Mortality in HIV-infected Zimbabwean Infants

被引：6
作者：
Mutasa, Kuda [1 ]
Ntozini, Robert [1 ]
Prendergast, Andrew [1 ,2 ,3 ]
Iliff, Peter [1 ]
Rukobo, Sandra [1 ]
Moulton, Lawrence H. [3 ]
Ward, Brian J. [4 ]
Humphrey, Jean H. [1 ,2 ]
机构：
[1] Zvitambo Project, Harare, Zimbabwe
[2] Univ London, Ctr Paediat, Blizard Inst, London WC1E 7HU, England
[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA
[4] McGill Univ, Res Inst, Ctr Hlth, Montreal, PQ, Canada
来源：
PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2012年 / 31卷 / 09期
关键词：
HIV; infants; viral load; mortality; disease progression; DISEASE PROGRESSION; TRANSMISSION; ASSOCIATION; THERAPY; RNA;
D O I：
10.1097/INF.0b013e318266aac2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Among 453 untreated HIV-infected Zimbabwean infants, 6-week viral load was the only infant factor that independently predicted mortality. Infants with viral load >= 1.59 million copies/mL (cohort median) had 3-fold increased mortality through 6 months (hazard ratio 3.07 [95% confidence interval: 2.16, 4.38]; P < 0.001) and 2-fold increased mortality through 12 months (hazard ratio 2.03 [95% confidence interval: 1.41, 2.91]; P < 0.001], compared with infants with viral load below the median.
引用
收藏
页码：948 / 950
页数：3
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