SDF-1/CXCR4 Axis Promotes MSCs to Repair Liver Injury Partially through Trans-Differentiation and Fusion with Hepatocytes

被引：30

作者：

Hao, Ning-Bo ^{[1
]}

Li, Chang-Zhu ^{[1
]}

Lu, Mu-Han ^{[1
]}

Tang, Bo ^{[1
]}

Wang, Su-Min ^{[1
]}

Wu, Yu-Yun ^{[1
]}

Liang, Guang-Ping ^{[2
]}

Yang, Shi-Ming ^{[1
]}

机构：

[1] Third Mil Med Univ, Xinqiao Hosp, Dept Gastroenterol, Chongqing 400037, Peoples R China

[2] Third Mil Med Univ, Inst Burn Res, Southwest Hosp, Chongqing 400038, Peoples R China

来源：

STEM CELLS INTERNATIONAL | 2015年 / 2015卷

关键词：

MESENCHYMAL STEM-CELLS; MARROW STROMAL CELLS; BONE-MARROW; PRECURSOR CELLS; ISCHEMIC BRAIN; RAT-LIVER; MIGRATION; TRANSPLANTATION; INDUCTION; CXCR4;

D O I：

10.1155/2015/960387

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

MSCs have become a popular target for developing end-stage liver therapies. In this study, two models of bone marrow chimeric mice were used to construct the liver failure models. Then it was found that MSCs can transdifferentiate into hepatocyte-like cells and these hepatocyte-like cells can significantly express albumin. Furthermore it was also found that MSCs can fuse with the hepatocytes and these cells had the proliferation activity. However, the percentage of transdifferentiation was significantly higher than fusion. So it was considered that MSCs which transdifferentiated into hepatocyte-likes cells played important roles for repairing the injuring liver function.

引用

页数：10

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