Novel, nonreflex tests detect analgesic action in rodents at clinically relevant concentrations

被引：28

作者：

Andrews, Nick ^{[1
]}

Harper, Sinead ^{[1
]}

Issop, Yasmin ^{[1
]}

Rice, Andrew S. C. ^{[2
]}

机构：

[1] Pfizer Labs, Pain & Sensory Disorders Res Unit, Sandwich, Kent, England

[2] Univ London Imperial Coll Sci Technol & Med, Pain Res Grp, Sect Anaesthet Pain Med & Intens Care, Fac Med, London, England

来源：

ANIMAL MODELS: THEIR VALUE IN PREDICTING DRUG EFFICACY AND TOXICITY | 2011年 / 1245卷

关键词：

burrowing; chronic pain; rat; ANIMAL-MODELS;

D O I：

10.1111/j.1749-6632.2011.06342.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We propose that predictive validity of tests for analgesia may be improved by looking to reinstate specific, innate behaviors suppressed by pain, e. g., burrowing, because effective plasma concentrations in the rat are closer to effective clinical plasma concentrations than those generally used in rodent reflex withdrawal assays.

引用

页码：11 / 13

页数：3

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