Effect of hypothyroidism on insulin sensitivity and glucose tolerance in dogs

被引:9
作者
Hofer-Inteeworn, Natalie [1 ]
Panciera, David L. [1 ]
Monroe, William E. [1 ]
Saker, Korinn E. [2 ]
Davies, Rebecca Hegstad [3 ]
Refsal, Kent R. [4 ]
Kemnitz, Joseph W. [5 ,6 ]
机构
[1] Virginia Tech, Dept Small Anim Clin Sci, Virginia Maryland Reg Coll Vet Med, Blacksburg, VA 24061 USA
[2] Virginia Tech, Dept Large Anim Clin Sci, Virginia Maryland Reg Coll Vet Med, Blacksburg, VA 24061 USA
[3] Univ Minnesota, Coll Vet Med, Vet Diagnost Lab, St Paul, MN 55108 USA
[4] Michigan State Univ, Diagnost Ctr Populat & Anim Hlth, Coll Vet Med, Lansing, MI 48824 USA
[5] Univ Wisconsin, Inst Clin & Translat Res, Sch Med & Publ Hlth, Madison, WI 53715 USA
[6] Univ Wisconsin, Dept Physiol, Sch Med & Publ Hlth, Madison, WI 53715 USA
关键词
THYROXINE REPLACEMENT THERAPY; URINARY CORTISOL METABOLITES; TRANSPORTER GENE-EXPRESSION; GROWTH-HORMONE-SECRETION; THYROID-HORMONE; MINIMAL-MODEL; SKELETAL-MUSCLE; QUANTITATIVE ESTIMATION; BLOOD-SUGAR; RESISTANCE;
D O I
10.2460/ajvr.73.4.529
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Objective-To determine the effects of hypothyroidism on insulin sensitivity, glucose tolerance, and concentrations of hormones counter-regulatory to insulin in dogs. Animals-8 anestrous mixed-breed bitches with experimentally induced hypothyroidism and 8 euthyroid control dogs. Procedures-The insulin-modified frequently sampled IV glucose tolerance test and minimal model analysis were used to determine basal plasma insulin and glucose concentrations, acute insulin response to glucose, insulin sensitivity, glucose effectiveness, and disposition index. Growth hormone response was assessed by stimulation and suppression tests. Additionally, basal serum growth hormone (GH) and insulin-like growth factor-1 (IGF-1) concentrations and urine cortisol-to-creatinine concentration ratios were measured and dual energy x-ray absorptiometry was performed to evaluate body composition. Results-Insulin sensitivity was lower in the hypothyroid group than in the euthyroid group, whereas acute insulin response to glucose was higher. Glucose effectiveness and disposition index were not different between groups. Basal serum GH and IGF-1 concentrations as well as abdominal fat content were high in hypothyroid dogs, but urine cortisol-to-creatinine concentration ratios were unchanged. Conclusions and Clinical Relevance-Hypothyroidism appeared to negatively affect glucose homeostasis by inducing insulin resistance, but overall glucose tolerance was maintained by increased insulin secretion in hypothyroid dogs. Possible factors affecting insulin sensitivity are high serum GH and IGF-1 concentrations and an increase in abdominal fat. In dogs with diseases involving impaired insulin secretion such as diabetes mellitus, concurrent hypothyroidism can have important clinical implications. (Am J Vet Res 2012;73:529-538)
引用
收藏
页码:529 / 538
页数:10
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