A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer

被引：19

作者：

Wang, Lixin ^{[1
]}

Zhang, Daoqiang ^{[1
,2
]}

Zhang, Changwen ^{[1
]}

Zhang, Shuping ^{[1
]}

Wang, Zhe ^{[1
]}

Qu, Chen ^{[1
]}

Liu, Sijin ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Ecoenvironm Sci Res Ctr, Beijing 100085, Peoples R China

[2] Wendeng Cent Hosp, Weifang Med Coll, Weihai 264400, Peoples R China

来源：

ONCOLOGY LETTERS | 2012年 / 3卷 / 01期

基金：

中国国家自然科学基金;

关键词：

microRNA; tumor-initiating cells; cancer stem cells; breast cancer; microarray; EMBRYONIC STEM-CELLS; SELF-RENEWAL; DIFFERENTIATION; PROLIFERATION; TUMORIGENICITY; METASTASIS; MATURATION; MODULATE; MIRNAS; LIN-28;

D O I：

10.3892/ol.2011.431

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

microRNAs (miRNAs) are involved in controlling tumor behaviors either as oncogenes or tumor suppressors. To elucidate the role of miRNAs in the regulation of tumor initiation, we delineated the microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer. A group of miRNAs were differentially expressed in MDA-MB-231 and SUM1315 cells (with a high proportion of breast cancer tumor-initiating cells, CD44(+)CD24(-/low) subpopulation) compared to MCF-7 cells (only a small proportion of CD44(+)CD24(-/low) cells). Among the differentially expressed miRNAs common to MDA-MB-231 and SUM1315, approximately 46% of them are suggested to regulate the 'stemness' of stem cells or progenitor cells. Taken together, these findings suggested that miRNAs contribute to the maintenance of tumor-initiating properties and indicate the potential value of the miRNA expression signature in characterizing or predicting the features (including metastasis) of breast cancer.

引用

页码：119 / 124

页数：6

共 48 条

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