CIRCULATING TUMOUR CELLS AND CIRCULATING ENDOTHELIAL CELLS AS BIOMARKERS IN ONCOLOGY

被引：4

作者：

Strijbos, M. H. ^{[1
]}

机构：

[1] Ghent Univ Hosp, Dept Med Oncol, B-9000 Ghent, Belgium

来源：

ACTA CLINICA BELGICA | 2011年 / 66卷 / 05期

关键词：

circulating tumour cells; circulating endothelial cells; bionnarkers; cancer; METASTATIC COLORECTAL-CANCER; RESISTANT PROSTATE-CANCER; BREAST-CANCER; ANGIOGENESIS; CARCINOMA; SURVIVAL; CHEMOTHERAPY; BEVACIZUMAB; SUNITINIB; BENEFIT;

D O I：

10.2143/ACB.66.5.2062584

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Circulating tumour cells (CTC) and circulating endothelial cells (CEC) are considered promising biomarkers for tumour aggressiveness and vascular damage. Their number in the blood of cancer patients has already demonstrated to be of prognostic and predictive value in several studies. In addition, the molecular characterization of these cells may provide novel insight in the growth and dissemination of cancer, and help the development of new anti-neoplastic drugs. Therefore, many attempts have been made to reliably detect these extremely rare cells in the blood. In this review, we address the detection, applicability and results from clinical trials for both CTC and CEC.

引用

页码：332 / 336

页数：5

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