Application of Sodium Selenite in the Prevention and Treatment of Cancers

被引:94
作者
Kieliszek, Marek [1 ]
Lipinski, Boguslaw [1 ]
Blazejak, Stanislaw [1 ]
机构
[1] Warsaw Univ Life Sci SGGW, Fac Food Sci, Dept Biotechnol Microbiol & Food Evaluat, Nowoursynowska 159 C, PL-02776 Warsaw, Poland
关键词
selenium; cancer; fibrin; parafibrin; polymer; blood; CELL-DEATH; LYMPHEDEMA; METABOLISM; APOPTOSIS; CHEMOPREVENTION; MECHANISMS; CARCINOMA; DIAGNOSIS; TOXICITY; TRIAL;
D O I
10.3390/cells6040039
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Selenium is an essential trace element that occurs in nature, in both inorganic and organic forms. This element participates in numerous biochemical processes, including antioxidant potential, but the mechanism of its anti-cancer action is still not well known. It should be noted that the anti-cancer properties of selenium depends on its chemical form, therapeutic doses, and the tumor type. Higher nutritional doses of selenium can stimulate human immune system. There are several hypotheses concerning the anticancer activity of selenium, including oxidation of sulfhydryl groups in proteins causing their conformational alterations. Conformational changes in proteins have the ability to weaken the activity of enzymes involved in the metabolism of cancer cells. In case of human fibrinogen sodium selenite, but not selenate, it inhibits protein disulfide exchange reactions, thus preventing formation of a hydrophobic polymer termed parafibrin, circulatory accumulation, of which is associated with numerous degenerative diseases. Parafibrin can specifically form a protein coat around tumor cells that is completely resistant to degradation induced with lymphocyte protease. In this way, cancer cells become protected against destruction by the organism's immune system. Other possible mechanisms of anticancer action of selenium are being still investigated.
引用
收藏
页数:8
相关论文
共 44 条
  • [1] Selenium and Bladder Cancer Risk: a Meta-analysis
    Amaral, Andre F. S.
    Cantor, Kenneth P.
    Silverman, Debra T.
    Malats, Nuria
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2010, 19 (09) : 2407 - 2415
  • [2] Selenium in the prevention of human cancers
    Björnstedt M.
    Fernandes A.P.
    [J]. EPMA Journal, 2010, 1 (3) : 389 - 395
  • [3] Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study
    Brodin, Ola
    Eksborg, Staffan
    Wallenberg, Marita
    Asker-Hagelberg, Charlotte
    Larsen, Erik H.
    Mohlkert, Dag
    Lenneby-Helleday, Clara
    Jacobsson, Hans
    Linder, Stig
    Misra, Sougat
    Bjornstedt, Mikael
    [J]. NUTRIENTS, 2015, 7 (06): : 4978 - 4994
  • [4] Chen JS, 2012, ASIA PAC J CLIN NUTR, V21, P320
  • [5] Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin a randomized controlled trial - A randomized controlled trial
    Clark, LC
    Combs, GF
    Turnbull, BW
    Slate, EH
    Chalker, DK
    Chow, J
    Davis, LS
    Glover, RA
    Graham, GF
    Gross, EG
    Krongrad, A
    Lesher, JL
    Park, HK
    Sanders, BB
    Smith, CL
    Taylor, JR
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 276 (24): : 1957 - 1963
  • [6] Selenium in global food systems
    Combs, GF
    [J]. BRITISH JOURNAL OF NUTRITION, 2001, 85 (05) : 517 - 547
  • [7] Selenium: an element for life
    Duntas, Leonidas H.
    Benvenga, Salvatore
    [J]. ENDOCRINE, 2015, 48 (03) : 756 - 775
  • [8] Selenium compounds as therapeutic agents in cancer
    Fernandes, Aristi P.
    Gandin, Valentina
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2015, 1850 (08): : 1642 - 1660
  • [9] PRODUCTS OF THE REACTION OF SELENITE WITH INTRACELLULAR SULFHYDRYL COMPOUNDS
    FRENKEL, GD
    FALVEY, D
    MACVICAR, C
    [J]. BIOLOGICAL TRACE ELEMENT RESEARCH, 1991, 30 (01) : 9 - 18
  • [10] Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase
    Ganther, HE
    [J]. CARCINOGENESIS, 1999, 20 (09) : 1657 - 1666