Emerging Concepts in the Molecular Basis of Pulmonary Arterial Hypertension Part I: Metabolic Plasticity and Mitochondrial Dynamics in the Pulmonary Circulation and Right Ventricle in Pulmonary Arterial Hypertension

被引:158
|
作者
Ryan, John J. [1 ]
Archer, Stephen L. [2 ]
机构
[1] Univ Utah, Dept Med, Div Cardiovasc Med, Salt Lake City, UT 84112 USA
[2] Queens Univ, Dept Med, Kingston, ON K7L 3N6, Canada
基金
加拿大创新基金会;
关键词
glucose oxidation; glycolysis; heart failure; hypertension; pulmonary; mitochondria; mitochondrial dynamics; positron emission tomography; CONGENITAL LACTIC-ACIDOSIS; BREAST-CANCER CELLS; SUPEROXIDE PRODUCTION; THERAPEUTIC TARGET; CARDIAC-MUSCLE; HEART-FAILURE; DICHLOROACETATE; RATS; EXPRESSION; FISSION;
D O I
10.1161/CIRCULATIONAHA.114.006979
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:1691 / 1702
页数:12
相关论文
共 50 条
  • [31] Metabolic Reprogramming of the Right Ventricle and Pulmonary Arteries in a Flow-Associated Pulmonary Arterial Hypertension Rat Model
    Liu, Dongli
    Qin, Suyuan
    Su, Danyan
    Wang, Kai
    Huang, Yanyun
    Huang, Yuqin
    Pang, Yusheng
    ACS OMEGA, 2022, 7 (01): : 1273 - 1287
  • [32] Mitochondrial dysfunction in pulmonary arterial hypertension
    Zhang, Weiwei
    Liu, Bo
    Wang, Yazhou
    Zhang, Hengli
    He, Lang
    Wang, Pan
    Dong, Mingqing
    FRONTIERS IN PHYSIOLOGY, 2022, 13
  • [33] Mitochondrial Haplogroups In Pulmonary Arterial Hypertension
    Farha, S.
    Comhair, S. A. A.
    Aldred, M. A.
    Erzurum, S. C.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2014, 189
  • [34] The Metabolic Theory of Pulmonary Arterial Hypertension
    Paulin, Roxane
    Michelakis, Evangelos D.
    CIRCULATION RESEARCH, 2014, 115 (01) : 148 - 164
  • [35] Metabolic Dysfunction in Pulmonary Arterial Hypertension
    Assad, Tufik R.
    Hemnes, Anna R.
    CURRENT HYPERTENSION REPORTS, 2015, 17 (04)
  • [36] F2-Isoprostanes An Emerging Pulmonary Arterial Hypertension Biomarker and Potential Link to the Metabolic Theory of Pulmonary Arterial Hypertension?
    Dromparis, Peter
    Michelakis, Evangelos D.
    CHEST, 2012, 142 (04) : 816 - 820
  • [37] Metabolic Dysfunction in Pulmonary Arterial Hypertension
    Tufik R. Assad
    Anna R. Hemnes
    Current Hypertension Reports, 2015, 17
  • [38] Mitochondrial alterations in pulmonary arterial smooth muscle cells in pulmonary arterial hypertension
    Sommer, Natascha
    Krug, Philipp
    Waisbrod, Sharon
    Pak, Oleg
    Ghofrani, Hossein A.
    Seeger, Werner
    Weissmann, Norbert
    MITOCHONDRION, 2010, 10 (02) : 229 - 229
  • [39] Current Understanding of the Right Ventricle Structure and Function in Pulmonary Arterial Hypertension
    Sharifi Kia, Danial
    Kim, Kang
    Simon, Marc A.
    FRONTIERS IN PHYSIOLOGY, 2021, 12
  • [40] Reducing the pressure in pulmonary arterial hypertension: sotatercept, haemodynamics and the right ventricle
    Price, Laura C.
    McCabe, Colm
    Weatherald, Jason
    EUROPEAN RESPIRATORY JOURNAL, 2023, 62 (03)