Cleaning up Polyketide Synthases

被引：3

作者：

Kwan, Jason C. ^{[1
]}

Schmidt, Eric W. ^{[1
]}

机构：

[1] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA

来源：

CHEMISTRY & BIOLOGY | 2012年 / 19卷 / 03期

关键词：

IN-VIVO; ACYLTRANSFERASE; BIOSYNTHESIS; PATHWAY;

D O I：

10.1016/j.chembiol.2012.03.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Complex biosynthetic enzymes such as polyketide synthases make mistakes. In this issue of Chemistry & Biology, Jensen et al. report that a discrete family of acyltransferases is responsible for error correction, hydrolyzing key biosynthetic intermediates from a multi-enzyme complex. This activity might find use in understanding polyketide biosynthesis, particularly in uncultivated organisms and in tailoring the synthesis of small molecules.

引用

页码：309 / 311

页数：3

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