Effect of hydroxychloroquine treatment on pro-inflammatory cytokines and disease activity in SLE patients: data from LUMINA (LXXV), a multiethnic US cohort

被引:135
|
作者
Willis, R.
Seif, A. M.
McGwin, G., Jr. [3 ]
Martinez-Martinez, L. A.
Gonzalez, E. B.
Dang, N.
Papalardo, E.
Liu, J. [3 ]
Vila, L. M. [2 ]
Reveille, J. D. [4 ]
Alarcon, G. S. [3 ]
Pierangeli, S. S. [1 ]
机构
[1] Univ Texas Med Branch, Div Rheumatol Internal Med, Galveston, TX 77555 USA
[2] Univ Puerto Rico, San Juan, PR 00936 USA
[3] Univ Alabama Birmingham, Birmingham, AL USA
[4] Univ Texas Houston Hlth Sci Ctr, Houston, TX USA
关键词
Lupus; hydroxychloroquine; biomarkers of inflammation; biomarkers of thrombosis; SYSTEMIC-LUPUS-ERYTHEMATOSUS; 3; ETHNIC-GROUPS; ANTIPHOSPHOLIPID ANTIBODIES; ANTICARDIOLIPIN ANTIBODIES; ANTIMALARIAL-DRUGS; INTERFERON-ALPHA; RISK-FACTORS; TNF-ALPHA; THROMBOSIS; CELLS;
D O I
10.1177/0961203312437270
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: We sought to determine the effect of hydroxychloroquine therapy on the levels proinflammatory/prothrombotic markers and disease activity scores in patients with systemic lupus erythematosus (SLE) in a multiethnic, multi-center cohort (LUMINA). Methods: Plasma/serum samples from SLE patients (n = 35) were evaluated at baseline and after hydroxychloroquine treatment. Disease activity was assessed using SLAM-R scores. Interferon (IFN)-alpha 2, interleukin (IL)-1 beta, IL-6, IL-8, inducible protein (IP)-10, monocyte chemotactic protein-1, tumor necrosis factor (TNF)-alpha and soluble CD40 ligand (sCD40L) levels were determined by a multiplex immunoassay. Anticardiolipin antibodies were evaluated using ELISA assays. Thirty-two frequency-matched plasma/serum samples from healthy donors were used as controls. Results: Levels of IL-6, IP-10, sCD40L, IFN-alpha and TNF-alpha were significantly elevated in SLE patients versus controls. There was a positive but moderate correlation between SLAM-R scores at baseline and levels of IFN-alpha (p = 0.0546). Hydroxychloroquine therapy resulted in a significant decrease in SLAM-R scores (p = 0.0157), and the decrease in SLAM-R after hydroxychloroquine therapy strongly correlated with decreases in IFN-alpha (p = 0.0087). Conclusions: Hydroxychloroquine therapy resulted in significant clinical improvement in SLE patients, which strongly correlated with reductions in IFN-alpha levels. This indicates an important role for the inhibition of endogenous TLR activation in the action of hydroxychloroquine in SLE and provides additional evidence for the importance of type I interferons in the pathogenesis of SLE. This study underscores the use of hydroxychloroquine in the treatment of SLE. Lupus (2012) 21, 830-835.
引用
收藏
页码:830 / 835
页数:6
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