Toxicity of Transition Metal Oxide Nanoparticles: Recent Insights from in vitro Studies

被引:160
作者
Huang, Yue-Wern [1 ]
Wu, Chi-heng
Aronstam, Robert S.
机构
[1] Missouri Univ Sci & Technol, Dept Biol Sci, Rolla, MO 65409 USA
关键词
nanoparticle; toxicity; metal oxide; oxidative stress; calcium homeostasis; signal transduction; LUNG EPITHELIAL-CELLS; TITANIUM-DIOXIDE NANOPARTICLES; WALLED CARBON NANOTUBES; DNA-ADDUCT FORMATION; OXIDATIVE STRESS; ZINC-OXIDE; SILICA NANOPARTICLES; IRON NANOPARTICLES; ENDOTHELIAL-CELLS; INHALED PARTICLES;
D O I
10.3390/ma3104842
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Nanotechnology has evolved to play a prominent role in our economy. Increased use of nanomaterials poses potential human health risk. It is therefore critical to understand the nature and origin of the toxicity imposed by nanomaterials (nanotoxicity). In this article we review the toxicity of the transition metal oxides in the 4th period that are widely used in industry and biotechnology. Nanoparticle toxicity is compellingly related to oxidative stress and alteration of calcium homeostasis, gene expression, pro-inflammatory responses, and cellular signaling events. The precise physicochemical properties that dictate the toxicity of nanoparticles have yet to be defined, but may include element-specific surface catalytic activity (e.g., metallic, semiconducting properties), nanoparticle uptake, or nanoparticle dissolution. These in vitro studies substantially advance our understanding in mechanisms of toxicity, which may lead to safer design of nanomaterials.
引用
收藏
页码:4842 / 4859
页数:18
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