Effect of Cyclophosphamide on Expression of MMP-9 and TGF-β1 in Renal Tissue of Rats with Diabetes Mellitus

被引：4

作者：

Zhang, Yan ^{[1
]}

Wu, Ge ^{[2
]}

Hu, Xiaozhou ^{[1
]}

Zhang, Jin ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Nephrol, Affiliated Hosp 5, Zhengzhou 450052, Henan, Peoples R China

[2] Zhengzhou Univ, Dept Nephrol, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2015年 / 72卷 / 02期

关键词：

Diabetic nephropathy; Cyclophosphamide; Matrix metalloproteinase; Transforming growth factor-beta 1; TANDEM MASS-SPECTROMETRY; OXIDATIVE STRESS; NEPHROPATHY; PLASMA; BIOMARKERS;

D O I：

10.1007/s12013-014-0474-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetic nephropathy (DN) is a severe microvascular complication that occurs in diabetes patients. In this study, we investigated the effect of cyclophosphamide (CTX) on expression of matrix metalloproteinases (MMP-9) and transforming growth factor-beta 1 (TGF-beta 1) in renal tissue of rats with DN. We found CTX significantly reduces KI and blood glucose levels, microalbuminuria, and blood urea nitrogen. It also decreases the expression of TGF-beta 1 and increases the expression of MMP-9. Our data suggest CTX may reduce the excretion of urine proteins, alleviate kidney hypertrophy, and reduce blood glucose level through regulation of TGF-beta 1 and MMP-9 gene expression.

引用

页码：399 / 403

页数：5

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