GluR3 antibodies: Prevalence in focal epilepsy but no specificity for Rasmussen's encephalitis

被引：117
作者：
Wiendl, H
Bien, CG
Bernasconi, P
Fleckenstein, B
Elger, CE
Dichgans, J
Mantegazza, R
Melms, A
机构：
[1] Univ Tubingen, Dept Neurol, D-72076 Tubingen, Germany
[2] Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany
[3] Univ Bonn, Dept Epileptol, D-5300 Bonn, Germany
[4] Ist Nazl Neurol Carlo Besta, Neuromuscular Res Dept, Milan, Italy
来源：
NEUROLOGY | 2001年 / 57卷 / 08期
关键词：
D O I：
10.1212/WNL.57.8.1511
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Eight patients with Rasmussen's encephalitis, 40 patients with noninflammatory focal epilepsy, 104 patients with various neurologic diseases, and 16 healthy donors were tested for the prevalence of antibodies against the GluR3 receptor in serum and CSF. Reactivities against different peptides derived from various portions of this glutamate receptor subtype were detectable in a significantly higher number of patients with focal epilepsy than in those with other neurologic diseases, but they were not specific for the diagnosis of Rasmussen's encephalitis.
引用
收藏
页码：1511 / 1514
页数：4
相关论文
共 10 条
  • [1] Rasmussen's encephalitis: a challenge to neuroimmunology
    Aarli, JA
    [J]. CURRENT OPINION IN NEUROLOGY, 2000, 13 (03) : 297 - 299
  • [2] Glutamate receptor GluR3 antibodies and death of cortical cells
    He, XP
    Patel, M
    Whitney, KD
    Janumpalli, S
    Tenner, A
    McNamara, JO
    [J]. NEURON, 1998, 20 (01) : 153 - 163
  • [3] ANTISERUM TO BRAIN GANGLIOSIDES PRODUCES RECURRENT EPILEPTIFORM ACTIVITY
    KARPIAK, SE
    GRAF, L
    RAPPORT, MM
    [J]. SCIENCE, 1976, 194 (4266) : 735 - 737
  • [4] IMMUNOLOGICAL MODEL OF EPILEPSY - EPILEPTIFORM ACTIVITY INDUCED BY FRAGMENTS OF ANTIBODY TO GM1 GANGLIOSIDE
    KARPIAK, SE
    HUANG, YYL
    RAPPORT, MM
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 1982, 3 (01) : 15 - 21
  • [5] Recurrent convulsive seizures in animals produced by immunologic and chemical means
    Kopeloff, LM
    Barrera, SE
    Kopeloff, N
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 1942, 98 (06) : 881 - 902
  • [6] Emerging insights into the genesis of epilepsy
    McNamara, JO
    [J]. NATURE, 1999, 399 (6738) : A15 - A22
  • [7] Epilepsy: an autoimmune disease?
    Palace, J
    Lang, B
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2000, 69 (06) : 711 - 714
  • [8] AUTOANTIBODIES TO GLUTAMATE-RECEPTOR GLUR3 IN RASMUSSENS ENCEPHALITIS
    ROGERS, SW
    ANDREWS, PI
    GAHRING, LC
    WHISENAND, T
    CAULEY, K
    CRAIN, B
    HUGHES, TE
    HEINEMANN, SF
    MCNAMARA, JO
    [J]. SCIENCE, 1994, 265 (5172) : 648 - 651
  • [9] So NK, 1997, EPILEPSY COMPREHENSI, P2379
  • [10] GLUTAMATE-RECEPTOR ANTIBODIES ACTIVATE A SUBSET OF RECEPTORS AND REVEAL AN AGONIST BINDING-SITE
    TWYMAN, RE
    GAHRING, LC
    SPIESS, J
    ROGERS, SW
    [J]. NEURON, 1995, 14 (04) : 755 - 762
1