Parental subfecundity and risk of decreased semen quality in the male offspring: A follow-up study

被引:17
作者
Ramlau-Hansen, C. H. [1 ]
Thulstrup, A. M. [1 ]
Olsen, J. [2 ]
Bonde, J. P. [1 ]
机构
[1] Aarhus Univ Hosp, Dept Occupat Med, DK-8000 Aarhus C, Denmark
[2] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90024 USA
关键词
fertility; gonadal steroid hormones; heredity; prenatal exposure delayed effects; semen; sperm count;
D O I
10.1093/aje/kwn076
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
A few studies have found poor semen quality in sons whose mothers have received fertility treatment, but it is unknown whether the poor semen quality is related to the infertility treatment or to infertility per se, for example, whether it is caused by hereditable factors. Using data from a population-based, Danish follow-up study conducted in 2005-2006, the authors of the present study examined whether sons of subfertile couples who had not received fertility treatment had poorer semen quality than sons of fertile couples. Among the 311 participants, an inverse association between parental waiting time to pregnancy and both semen volume and total sperm count was observed (p trend = 0.04 and p trend = 0.046, respectively). Semen volume in sons of subfertile parents (pregnant after >= 1 years) was 19% lower in comparison with that in sons of parents whose waiting time to pregnancy was 0-6 months (p = 0.02). Additionally, sperm concentration and percentage of morphologically normal sperm were, respectively, 22% (p = 0.15) and 23% (p = 0.13) lower in sons of subfertile parents. Results suggest a small-to-moderate effect of parental subfecundity on semen quality in sons, comparable with the hypothesis that low fecundity has at least partly hereditable causes.
引用
收藏
页码:1458 / 1464
页数:7
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