Construction of anti-bacterial multilayer films via layer-by-layer electro, static self-assembly of chitosan and heparin

Chitosan as an antibacterial agent and heparin as an anti-adhesive agent were alternatively deposited onto aminolyzed poly(ethylene terephthalate) (PET) to construct anti-adhesive and antibacterial multilayer films. The contact angle and UV data verified the progressive build-up of the multilayer film by alternate deposition of the polyelectrolytes. PRT experiment and in vitro antibacterial assay indicated that the multilayer-modified PET films had much better hemocompatibility and much stronger antibacterial performance than unmodified PET. Such an easy processing and shape-independent method to prepare an anti-adhesive and antibacterial surface may have a good potential for surface modification of cardiovascular devices.