SIRT1 and aging related signaling pathways

被引：472

作者：

Chen, Cui ^{[1
]}

Zhou, Min ^{[1
]}

Ge, Yuchen ^{[1
]}

Wang, Xiaobo ^{[1
,2
]}

机构：

[1] Dali Univ, Sch Basic Med, Dali 671000, Yunnan, Peoples R China

[2] Key Lab Univ Cell Biol Yunnan Prov, Dali 671000, Yunnan, Peoples R China

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2020年 / 187卷

基金：

中国国家自然科学基金;

关键词：

SIRT1; Aging; Signaling pathways; NAD(+); Deacetylate; EXTENDS LIFE-SPAN; NF-KAPPA-B; OXIDATIVE STRESS; SACCHAROMYCES-CEREVISIAE; CALORIC RESTRICTION; PROTECTIVE ROLE; STEM-CELLS; RESVERATROL; ACTIVATION; MODULATION;

D O I：

10.1016/j.mad.2020.111215

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging is a biological phenomenon in which the structure and function of organisms declining with the increasing of age. It has become a major risk factor of human diseases, including diabetes, cancers, cardiovascular diseases and neurodegenerative diseases. Silencing information regulator 2 related enzyme 1(sirtuin1, SIRT1) is an NAD(+)-dependent deacetylase, which has been reported to be involved in the regulation of cellular senescence and aging. The expression of SIRT1 is diminished with aging in mice. By contrast, increased expression of SIRT1 is sufficient to extend lifespan in yeast, caenorhabditis elegans and mice. In this review, the relationship between SIRT1 and aging and various signaling networks associated with aging, including NF-kappa B, AMPK, mTOR, P53, PGC1 alpha, and FoxOs will be discussed. Meanwhile, the potential therapeutic strategies of targeting SIRT1 to anti-aging are also addressed.

引用

页数：7

共 99 条

[1] Sirtuins and FoxOs in osteoporosis and osteoarthritis [J].

Almeida, Maria ;

Porter, Ryan M. .

BONE, 2019, 121 :284-292

[2]

[Anonymous], [No title captured]

[3] Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy [J].

Armour, Sean M. ;

Baur, Joseph A. ;

Hsieh, Sherry N. ;

Land-Bracha, Abigail ;

Thomas, Sheila M. ;

Sinclair, David A. .

AGING-US, 2009, 1 (06) :515-528

[4] Drosophila Longevity Assurance Conferred by Reduced Insulin Receptor Substrate Chico Partially Requires d4eBP [J].

Bai, Hua ;

Post, Stephanie ;

Kang, Ping ;

Tatar, Marc .

PLOS ONE, 2015, 10 (08)

[5] Therapeutic potential of resveratrol:: the in vivo evidence [J].

Baur, Joseph A. ;

Sinclair, David A. .

NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (06) :493-506

[6] Are sirtuins viable targets for improving healthspan and lifespan? [J].

Baur, Joseph A. ;

Ungvari, Zoltan ;

Minor, Robin K. ;

Le Couteur, David G. ;

de Cabo, Rafael .

NATURE REVIEWS DRUG DISCOVERY, 2012, 11 (06) :443-461

[7] Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1 [J].

Bitterman, KJ ;

Anderson, RM ;

Cohen, HY ;

Latorre-Esteves, M ;

Sinclair, DA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (47) :45099-45107

[8] Inhibition of S6K by resveratrol: In search of the purpose [J].

Blagosklonny, Mikhail V. .

AGING-US, 2009, 1 (06) :511-514

[9] Age Related Changes in NAD plus Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats (Publication with Expression of Concern. See vol. 17, 2022) [J].

Braidy, Nady ;

Guillemin, Gilles J. ;

Mansour, Hussein ;

Chan-Ling, Tailoi ;

Poljak, Anne ;

Grant, Ross .

PLOS ONE, 2011, 6 (04)

[10] Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase [J].

Brunet, A ;

Sweeney, LB ;

Sturgill, JF ;

Chua, KF ;

Greer, PL ;

Lin, YX ;

Tran, H ;

Ross, SE ;

Mostoslavsky, R ;

Cohen, HY ;

Hu, LS ;

Cheng, HL ;

Jedrychowski, MP ;

Gygi, SP ;

Sinclair, DA ;

Alt, FW ;

Greenberg, ME .

SCIENCE, 2004, 303 (5666) :2011-2015

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