Effect of isofebrifugine on the proliferation and invasion of human gastric cancer cells via MMP

被引：7
作者：
Xu, Jin [1 ]
Wu, Jianbo [2 ]
Tang, Chuankang [1 ]
机构：
[1] Southwest Med Univ, Dept Gastroenterol, Affiliated Hosp, Luzhou, Peoples R China
[2] Southwest Med Univ, Drug Discovery Res Ctr, Luzhou, Peoples R China
来源：
CELLULAR AND MOLECULAR BIOLOGY | 2020年 / 66卷 / 01期
关键词：
Isofebrifugine; Proliferation; Invasion; Gastric cancer; MMP; MATRIX METALLOPROTEINASES; ANTIMALARIAL ACTIVITY; HALOFUGINONE; FEBRIFUGINE; MIGRATION; ROLES;
D O I：
10.14715/cmb/2019.66.1.4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Gastric cancer (GC) is one of the most common fatal cancers among gastrointestinal malignancies. At present, the treatment of gastric cancer involves a combination of surgery and chemotherapy. Isofebrifugine (IFE) is an alkaloid with many biological properties. In this study, results from MTT, scratch and invasion assays showed that IFE significantly inhibited the proliferation, migration and invasion of SGC7901 gastric cancer cells. Through RT-PCR and Western blot experiments, it was revealed that IFE, significantly inhibited the mRNA and protein expressions of MMP-2, MMP-9 and SDF-1 which are closely related to cancer invasion and metastasis. Thus, IFE possesses anti-gastric cancer properties.
引用
收藏
页码：27 / 31
页数：5
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共 28 条
  • [1] Natural products for cancer chemotherapy
    Demain, Arnold L.
    Vaishnav, Preeti
    [J]. MICROBIAL BIOTECHNOLOGY, 2011, 4 (06): : 687 - 699
  • [2] A Historical Overview of Natural Products in Drug Discovery
    Dias, Daniel A.
    Urban, Sylvia
    Roessner, Ute
    [J]. METABOLITES, 2012, 2 (02) : 303 - 336
  • [3] Advanced gastric cancer: Current treatment landscape and future perspectives
    Digklia, Antonia
    Wagner, Anna Dorothea
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2016, 22 (08) : 2403 - 2414
  • [4] Targeting Tumor Metabolism with Plant-Derived Natural Products: Emerging Trends in Cancer Therapy
    Guerra, Angela R.
    Duarte, Maria F.
    Duarte, Iola F.
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018, 66 (41) : 10663 - 10685
  • [5] Metabolites of febrifugine and its synthetic analogue by mouse liver S9 and their antimalarial activity against Plasmodium malaria parasite
    Hirai, S
    Kikuchi, H
    Kim, HS
    Begum, K
    Wataya, Y
    Tasaka, H
    Miyazawa, Y
    Yamamoto, K
    Oshima, Y
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (20) : 4351 - 4359
  • [6] Halofuginone induces the apoptosis of breast cancer cells and inhibits migration via downregulation of matrix metalloproteinase-9
    Jin, Mei Ling
    Park, Sun Young
    Kim, Young Hun
    Park, Geuntae
    Lee, Sang Joon
    [J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 2014, 44 (01) : 309 - 318
  • [7] Serum MMP7, MMP10 and MMP12 level as negative prognostic markers in colon cancer patients
    Klupp, Fee
    Neumann, Lena
    Kahlert, Christoph
    Diers, Johannes
    Halama, Niels
    Franz, Clemens
    Schmidt, Thomas
    Koch, Moritz
    Weitz, Juergen
    Schneider, Martin
    Ulrich, Alexis
    [J]. BMC CANCER, 2016, 16
  • [8] The Roles of Matrix Metalloproteinases in Pancreatic Cancer
    Knapinska, Anna M.
    Estrada, Christie-Anne
    Fields, Gregg B.
    [J]. MATRIX METALLOPROTEINASES AND TISSUE REMODELING IN HEALTH AND DISEASE: TARGET TISSUES AND THERAPY, 2017, 148 : 339 - 354
  • [9] Halofuginone inhibits NF-κB and p38 MAPK in activated T cells
    Leiba, M.
    Cahalon, L.
    Shimoni, A.
    Lider, O.
    Zanin-Zhorov, A.
    Hecht, I.
    Sela, U.
    Vlodavsky, I.
    Nagler, A.
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2006, 80 (02) : 399 - 406
  • [10] The chemistry and biology of febrifugine and halofuginone
    McLaughlin, Noel P.
    Evans, Paul
    Pines, Mark
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (07) : 1993 - 2004
123