Effects of amide constituents from pepper on adipogenesis in 3T3-L1 cells

被引：27

作者：

Zhang, Hailong ^{[1
]}

Matsuda, Hisashi ^{[1
]}

Nakamura, Seikou ^{[1
]}

Yoshikawa, Masayuki ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 11期

关键词：

Piper chaba; amide constituents; retrofractamide A; 3T3-L1; cells; adipogenesis; adiponectin;

D O I：

10.1016/j.bmcl.2008.04.052

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several amide constituents (piperlonguminine and retrofractamides A, B, and C) from the fruit of Piper chaba promoted adipogenesis of 3T3-L1 cells. Among them, retrofractamide A was the most active and significantly increased the amount of adiponectin released into the medium and the uptake of 2-deoxyglucose into the cells. Retrofractamide A also increased mRNA levels of adiponectin, peroxisome proliferator-activated receptor gamma 2 (PPAR gamma 2), glucose transporter 4 (GLUT4), and insulin receptor substrate 1 (IRS-1), but did not act as a PPAR gamma agonist different from troglitazone. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：3272 / 3277

页数：6

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