Effects of amide constituents from pepper on adipogenesis in 3T3-L1 cells

被引：27
|
作者：
Zhang, Hailong [1 ]
Matsuda, Hisashi [1 ]
Nakamura, Seikou [1 ]
Yoshikawa, Masayuki [1 ]
机构：
[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 11期
关键词：
Piper chaba; amide constituents; retrofractamide A; 3T3-L1; cells; adipogenesis; adiponectin;
D O I：
10.1016/j.bmcl.2008.04.052
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several amide constituents (piperlonguminine and retrofractamides A, B, and C) from the fruit of Piper chaba promoted adipogenesis of 3T3-L1 cells. Among them, retrofractamide A was the most active and significantly increased the amount of adiponectin released into the medium and the uptake of 2-deoxyglucose into the cells. Retrofractamide A also increased mRNA levels of adiponectin, peroxisome proliferator-activated receptor gamma 2 (PPAR gamma 2), glucose transporter 4 (GLUT4), and insulin receptor substrate 1 (IRS-1), but did not act as a PPAR gamma agonist different from troglitazone. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3272 / 3277
页数：6
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