Regioselective C-H bond functionalizations of acridines using organozinc reagents

被引:36
作者
Hyodo, Isao [1 ]
Tobisu, Mamoru [1 ,2 ]
Chatani, Naoto [1 ]
机构
[1] Osaka Univ, Fac Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Grad Sch Engn, Ctr Atom & Mol Technol, Suita, Osaka 5650871, Japan
关键词
RH(I)-CATALYZED DIRECT ARYLATION; NICKEL/LEWIS ACID CATALYSIS; SELECTIVE ALKENYLATION; AROMATIC HETEROCYCLES; PYRIDINE; DERIVATIVES; ACTIVATION; ALKYLATION; QUINOLINES; AGENTS;
D O I
10.1039/c1cc16582h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Despite the recent advance in C-H bond functionalization chemistry, the C-H bonds in the acridine ring system, which is an important scaffold in medicinal and material science, have met with limited success, due, in part, to the lack of activated C-H bonds adjacent to the ring nitrogen atom. Herein, several protocols that can effect the regioselective arylation and alkylation of acridines at the C-4 and C-9 positions are described.
引用
收藏
页码:308 / 310
页数:3
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