Regioselective C-H bond functionalizations of acridines using organozinc reagents

被引：36

作者：

Hyodo, Isao ^{[1
]}

Tobisu, Mamoru ^{[1
,2
]}

Chatani, Naoto ^{[1
]}

机构：

[1] Osaka Univ, Fac Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Engn, Ctr Atom & Mol Technol, Suita, Osaka 5650871, Japan

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 02期

关键词：

RH(I)-CATALYZED DIRECT ARYLATION; NICKEL/LEWIS ACID CATALYSIS; SELECTIVE ALKENYLATION; AROMATIC HETEROCYCLES; PYRIDINE; DERIVATIVES; ACTIVATION; ALKYLATION; QUINOLINES; AGENTS;

D O I：

10.1039/c1cc16582h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Despite the recent advance in C-H bond functionalization chemistry, the C-H bonds in the acridine ring system, which is an important scaffold in medicinal and material science, have met with limited success, due, in part, to the lack of activated C-H bonds adjacent to the ring nitrogen atom. Herein, several protocols that can effect the regioselective arylation and alkylation of acridines at the C-4 and C-9 positions are described.

引用

页码：308 / 310

页数：3

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