Absence of secondary structure in a carbopeptoid tetramer of a trans-5-aminomethyl-tetrahydrofuran-2-carboxylate

被引：41

作者：

Smith, MD

Long, DD

Martín, A

Marquess, DG

Claridge, TDW

Fleet, GWJ

机构：

[1] Oxford Ctr Mol Sci, Dyson Perrins Lab, Oxford OX1 3QY, England

[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

[3] Adv Med Inc, San Francisco, CA 94080 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 11期

关键词：

D O I：

10.1016/S0040-4039(99)00109-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Whereas trimers and tetramers of beta-C-D-arabinofuranosyl carbohydrate amino acids adopt well defined conformations based around a repealing beta-turn like structure, stabilised by (i, i-2) inter-residue hydrogen bonds, there is no indication of any secondary structure in the tetramer of the epimeric alpha-C-D-arabinoluranosyl carbohydrate amino acid, where the C-2 and C-5 substituents of the tetrahydrofuran ring are Irans to each other. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：2191 / 2194

页数：4

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