Multiple roles of m6A methylation in epithelial-mesenchymal transition

被引：7
作者：
Zhao, Xueru [1 ,2 ,3 ,4 ]
Li, Xue [1 ,2 ,3 ,4 ]
Li, Xiaohua [1 ,2 ,3 ,4 ]
机构：
[1] Henan Prov Peoples Hosp, 7 Weiwu Rd, Zhengzhou 450003, Peoples R China
[2] Henan Eye Hosp, Henan Eye Inst, Henan Key Lab Ophthalmol & Visual Sci, Zhengzhou, Peoples R China
[3] Zhengzhou Univ, Peoples Hosp, Zhengzhou, Peoples R China
[4] Henan Univ, Peoples Hosp, Zhengzhou, Peoples R China
来源：
MOLECULAR BIOLOGY REPORTS | 2022年 / 49卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Epithelial-mesenchymal transition; Mechanism; RNA modification; m(6)A methylation; CADHERIN GENE-EXPRESSION; PRE-MESSENGER-RNAS; TRANSCRIPTIONAL REPRESSOR; CROSS-LINKING; CARCINOMA; CELLS; MIGRATION; EMT; N-6-METHYLADENOSINE; METHYLTRANSFERASE;
D O I：
10.1007/s11033-022-07368-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Epithelial-mesenchymal transition (EMT) plays an important role in migration and invasion of cancer cell and the development of tissue fibrosis diseases. N-6-methyladenosine (m(6)A) is the most extensive type of RNA methylation and has aroused extensive interest in recent years. However, m(6)A methylation seems to play different roles in different cancer cells and tissue fibrotic diseases. To determine the function of m(6)A methylation in EMT, we summarized the molecular mechanism of EMT and recent progress in the regulation of EMT by m(6)A methylation, suggesting that m(6)A methylation targets EMT program by affecting the expression of transcription factors, EMT markers, long noncoding RNA and EMT-associated signaling pathways, which provides more possibilities for early diagnosis and treatment.
引用
收藏
页码：8895 / 8906
页数：12
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