Reduced default mode network connectivity in schizophrenia patients

被引：33

作者：

Pankow, Anne ^{[1
]}

Deserno, Lorenz ^{[1
,2
,3
]}

Walter, Martin ^{[3
,4
,6
]}

Fydrich, Thomas ^{[5
]}

Bermpohl, Felix ^{[1
]}

Schlagenhauf, Florian ^{[1
,2
]}

Heinz, Andreas ^{[1
]}

机构：

[1] Univ Med Berlin, Dept Psychiat & Psychotherapy, Charite, D-10117 Berlin, Germany

[2] Max Planck Inst Human Cognit & Brain Sci, Max Planck Fellow Grp Cognit & Affect Control Beh, Leipzig, Germany

[3] Univ Magdeburg, Dept Neurol, D-39106 Magdeburg, Germany

[4] Univ Magdeburg, Dept Psychiat, D-39106 Magdeburg, Germany

[5] Humboldt Univ, Dept Psychol, Berlin, Germany

[6] Leibniz Inst Neurobioloy, Magdeburg, Germany

来源：

SCHIZOPHRENIA RESEARCH | 2015年 / 165卷 / 01期

关键词：

Schizophrenia; Default mode network; Functional imaging; FUNCTIONAL CONNECTIVITY; BRAIN; METAANALYSIS; ACTIVATION;

D O I：

10.1016/j.schres.2015.03.027

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

In the present study, we explored possible alterations in the default mode network (DMN) and its functional connectivity in 41 schizophrenia patients and 42 age-matched healthy controls. Schizophrenia patients displayed reduced activation in the ventromedial prefrontal cortex, left superior temporal gyrus including auditory cortex and temporal pole. Psychophysiological interaction analysis revealed reduced connectivity between left superior temporal gyrus including auditory cortex and the left temporal pole in schizophrenia patients compared to healthy subjects. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：90 / 93

页数：4

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