Tract based spatial statistical analysis and voxel based morphometry of diffusion indices in temporal lobe epilepsy

被引：26
作者：
Afzali, Maryam [1 ]
Soltanian-Zadeh, Hamid [1 ,2 ]
Elisevich, Kost V. [3 ]
机构：
[1] Univ Tehran, Sch Elect & Comp Engn, Control & Intelligent Proc Ctr Excellence, Tehran 14395515, Iran
[2] Henry Ford Hosp, Image Anal Lab, Detroit, MI 48202 USA
[3] Henry Ford Hosp, Dept Neurosurg, Detroit, MI 48202 USA
来源：
COMPUTERS IN BIOLOGY AND MEDICINE | 2011年 / 41卷 / 12期
基金：
美国国家科学基金会;
关键词：
Diffusion tensor magnetic resonance imaging; Tract based spatial statistics; Voxel based morphometry; Fractional anisotropy; Ellipsoidal area ratio; Temporal lobe epilepsy; WHITE-MATTER; HIPPOCAMPAL; ABNORMALITIES; GRAY;
D O I：
10.1016/j.compbiomed.2011.05.006
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
White matter (WM) microstructure can be evaluated by diffusion tensor imaging (DTI). Tract-based spatial statistical (TBSS) analysis provides a means of assessing alterations in WM tracts. In this paper, both voxel-based morphometry (VBM) and TBSS are examined using DTI data of temporal lobe epilepsy (TLE) patients and nonepileptic subjects. In addition to fractional anisotropy (FA), ellipsoidal area ratio (EAR) is used in this study. Significant reductions of FA and EAR are identified by TBSS in the parahippocampal white matter. Because of methodological differences, TBSS detects more localized abnormalities than VBM, while the EAR is more sensitive to WM alteration than FA. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1082 / 1091
页数：10
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