Novel technologies for the discovery and quantitation of biomarkers of toxicity

被引：28
作者：
Collings, Fitz B. [1 ]
Vaidya, Vishal S. [1 ]
机构：
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Renal Div,Harvard Inst Med, Boston, MA 02115 USA
来源：
TOXICOLOGY | 2008年 / 245卷 / 03期
关键词：
D O I：
10.1016/j.tox.2007.11.020
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Reliable biomarkers of toxicity are necessary both for the safe conduct of pre-clinical and clinical trials, and are increasingly needed for accurate clinical evaluation of treatment regimens with the potential to cause tissue injury. Recent advances in technology have added several new tools to the biomarker screening toolkit and improved the throughput of existing quantitative assays. Genomics, proteomics, and metabolomics have provided a wealth of data in the search for predictive, specific biomarkers. Multiplexed ELISA-based assay systems, silicon nanowire arrays, and patterned paper present unique abilities for fast, efficient sample analysis over a broad dynamic range. Powerful integrative systems biology software and growing open-source data repositories offer new ways to share, reduce, and analyze data from multiple sources. Novel technologies reviewed here have the potential to significantly reduce assay time and cost and improve the sensitivity of screening methods for candidate biomarkers of toxicity. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：167 / 174
页数：8
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