Anticancer Activity and Modes of Action of (arene) ruthenium(II) Complexes Coordinated to C-, N-, and O-ligands

被引：16
|
作者：
Biersack, Bernhard [1 ]
机构：
[1] Univ Bayreuth, Organ Chem Lab, Univ Str 30, D-95440 Bayreuth, Germany
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2016年 / 16卷 / 10期
关键词：
Anticancer drugs; (Arene)Ru(II); DNA binding; Metastasis; Organometallic compounds; Ruthenium; HALF-SANDWICH COMPLEXES; IN-VITRO; ANTITUMOR-ACTIVITY; BIOLOGICAL-ACTIVITY; KINASE INHIBITORS; CELLULAR UPTAKE; DNA-BINDING; DRUGS; CISPLATIN; RU(II);
D O I：
10.2174/138955751610160503004623
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An overview of anticancer active (arene) ruthenium(II) complexes coordinated to period 2 element-based ligand systems, i.e., carbon-, nitrogen-, and oxygen-coordinated ligands, is provided in this mini-review. A bridge is forged from the large group of anticancer active ruthenium compounds with monodentate and chelating nitrogen ligands via complexes of O,O-chelating ligands to organometallic ruthenium derivatives coordinated to carbon. (Arene) ruthenium(II) complexes with reduced side-effects and enhanced efficacy against cancer are highlighted. Pertinent literature is covered up to 2014.
引用
收藏
页码：804 / 814
页数：11
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