Anticancer Activity and Modes of Action of (arene) ruthenium(II) Complexes Coordinated to C-, N-, and O-ligands

被引：16

作者：

Biersack, Bernhard ^{[1
]}

机构：

[1] Univ Bayreuth, Organ Chem Lab, Univ Str 30, D-95440 Bayreuth, Germany

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2016年 / 16卷 / 10期

关键词：

Anticancer drugs; (Arene)Ru(II); DNA binding; Metastasis; Organometallic compounds; Ruthenium; HALF-SANDWICH COMPLEXES; IN-VITRO; ANTITUMOR-ACTIVITY; BIOLOGICAL-ACTIVITY; KINASE INHIBITORS; CELLULAR UPTAKE; DNA-BINDING; DRUGS; CISPLATIN; RU(II);

D O I：

10.2174/138955751610160503004623

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An overview of anticancer active (arene) ruthenium(II) complexes coordinated to period 2 element-based ligand systems, i.e., carbon-, nitrogen-, and oxygen-coordinated ligands, is provided in this mini-review. A bridge is forged from the large group of anticancer active ruthenium compounds with monodentate and chelating nitrogen ligands via complexes of O,O-chelating ligands to organometallic ruthenium derivatives coordinated to carbon. (Arene) ruthenium(II) complexes with reduced side-effects and enhanced efficacy against cancer are highlighted. Pertinent literature is covered up to 2014.

引用

页码：804 / 814

页数：11

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