Anticancer Activity and Modes of Action of (arene) ruthenium(II) Complexes Coordinated to C-, N-, and O-ligands

被引：16

作者：

Biersack, Bernhard ^{[1
]}

机构：

[1] Univ Bayreuth, Organ Chem Lab, Univ Str 30, D-95440 Bayreuth, Germany

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2016年 / 16卷 / 10期

关键词：

Anticancer drugs; (Arene)Ru(II); DNA binding; Metastasis; Organometallic compounds; Ruthenium; HALF-SANDWICH COMPLEXES; IN-VITRO; ANTITUMOR-ACTIVITY; BIOLOGICAL-ACTIVITY; KINASE INHIBITORS; CELLULAR UPTAKE; DNA-BINDING; DRUGS; CISPLATIN; RU(II);

D O I：

10.2174/138955751610160503004623

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An overview of anticancer active (arene) ruthenium(II) complexes coordinated to period 2 element-based ligand systems, i.e., carbon-, nitrogen-, and oxygen-coordinated ligands, is provided in this mini-review. A bridge is forged from the large group of anticancer active ruthenium compounds with monodentate and chelating nitrogen ligands via complexes of O,O-chelating ligands to organometallic ruthenium derivatives coordinated to carbon. (Arene) ruthenium(II) complexes with reduced side-effects and enhanced efficacy against cancer are highlighted. Pertinent literature is covered up to 2014.

引用

页码：804 / 814

页数：11

共 68 条

[31] Structure, recognition, and processing of cisplatin-DNA adducts
Jamieson, ER
Lippard, SJ
[J]. CHEMICAL REVIEWS, 1999, 99 (09) : 2467 - 2498
[32] Arene ruthenium dichloro complexes containing isonicotinic ester ligands: Synthesis, molecular structure and cytotoxicity
Khan, Farooq-Ahmad
Therrien, Bruno
Suess-Fink, Georg
Zava, Olivier
Dyson, Paul J.
[J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2013, 730 : 49 - 56
[33] Ferrocene-induced lymphocyte activation and antitumor activity is mediated by redox-sensitive signaling
Kovjazin, R
Eldar, T
Patya, M
Vanichkin, A
Lander, HM
Novogrodsky, A
[J]. FASEB JOURNAL, 2003, 17 (01) : 467 - +
[34] A New Promising Application for Highly Cytotoxic Metal Compounds: η6-Areneruthenium(II) Phosphite Complexes for the Treatment of Alveolar Echinococcosis
Kuester, Tatiana
Lense, Nadine
Barna, Fabienne
Hemphill, Andrew
Kindermann, Markus K.
Heinicke, Joachim W.
Vock, Carsten A.
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (09) : 4178 - 4188
[35] Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder
Kurzwernhart, Andrea
Kandioller, Wolfgang
Bartel, Caroline
Baechler, Simone
Trondl, Robert
Muehlgassner, Gerhard
Jakupec, Michael A.
Arion, Vladimir B.
Marko, Doris
Keppler, Bernhard K.
Hartinger, Christian G.
[J]. CHEMICAL COMMUNICATIONS, 2012, 48 (40) : 4839 - 4841
[36] Arene-ruthenium(II) complexes containing 5-fluorouracil-1-methyl isonicotinate: Synthesis and characterization of their anticancer activity
Liu, Kuan-Guan
Cai, Xiao-Qing
Li, Xian-Chuan
Qin, Da-An
Hu, Mao-Lin
[J]. INORGANICA CHIMICA ACTA, 2012, 388 : 78 - 83
[37] Selective cytotoxic Ru(II) arene Cp* complex salts [R-PhRuCp*]+X- for X = BF4-, PF6-, and BPh4-
Loughrey, Bradley T.
Healy, Peter C.
Parsons, Peter G.
Williams, Michael L.
[J]. INORGANIC CHEMISTRY, 2008, 47 (19) : 8589 - 8591
[38] Synthesis, Molecular Structure, and Anticancer Activity of Cationic Arene Ruthenium Metallarectangles
Mattson, Johan
Govindaswamy, Padavattan
Renfrew, Anna K.
Dyson, Paul J.
Stepnicka, Petr
Suess-Fink, Georg
Therrien, Bruno
[J]. ORGANOMETALLICS, 2009, 28 (15) : 4350 - 4357
[39] Exploring biologically relevant chemical space with metal complexes
Meggers, Eric
[J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2007, 11 (03) : 287 - 292
[40] Influence of the spacer length on the in vitro anticancer activity of dinuclear ruthenium-arene compounds
Mendoza-Ferri, Maria-Grazia
Hartinger, Christian G.
Eichinger, Rene E.
Stolyarova, Natalya
Severin, Kay
Jakupec, Michael A.
Nazarov, Alexey A.
Keppler, Bernhard K.
[J]. ORGANOMETALLICS, 2008, 27 (11) : 2405 - 2407

← 1 2 3 4 5 6 7 →