Identification of the mouse neurochondrin promoter region and the responsible region for cell type specific gene regulation

被引：2
作者：
Dateki, M
Mochizuki, R
Yanai, K
Fukamizu, A [1 ]
机构：
[1] Univ Tsukuba, Inst Appl Biochem, Tsukuba, Ibaraki 3058572, Japan
[2] Univ Tsukuba, Ctr Tsukuba Adv Res Alliance, Tsukuba, Ibaraki 3058577, Japan
[3] Sumitomo Pharmaceut Co Ltd, Sumitomo Pharmaceut Res Ctr, Osaka 5540022, Japan
来源：
NEUROSCIENCE LETTERS | 2004年 / 356卷 / 02期
关键词：
neurochondrin; promoter; activating region; repressing region; cell type dependent effect; GATA family transcriptional factor;
D O I：
10.1016/j.neulet.2003.11.026
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neurochondrin is a cytoplasmic protein possibly involved in neurite outgrowth and chondrocyte differentiation. In the present study, we have identified 202 bp of the mouse neurochondrin minimal promoter sequences encompassing the transcriptional initiation site, and both of the activating and repressing regions in the first exon. These two regulatory regions in the first exon had a cell type dependent effect on the identified minimal promoter. In the regulatory region, the duplication of potential binding sites for GATA family transcriptional factors was observed. Prospective binding sites for sex determining region Y and c-Ets1 were also found in the minimal promoter region. These factors could be potential regulators for the mouse neurochondrin gene. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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页码：107 / 110
页数：4
相关论文
共 17 条
[1]  
AKIYAMA Y, TFSEARCH SEARCHING T
[2]   EXPRESSION OF ETS PROTO-ONCOGENES IN ASTROCYTES IN HUMAN CORTEX [J].
AMOUYEL, P ;
GEGONNE, A ;
DELACOURTE, A ;
DEFOSSEZ, A ;
STEHELIN, D .
BRAIN RESEARCH, 1988, 447 (01) :149-153
[3]   The Drosophila polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1 [J].
Brown, JL ;
Mucci, D ;
Whiteley, M ;
Dirksen, ML ;
Kassis, JA .
MOLECULAR CELL, 1998, 1 (07) :1057-1064
[4]  
Donohoe ME, 1999, MOL CELL BIOL, V19, P7237
[5]  
GOLDBERG Y, 1994, J BIOL CHEM, V269, P16566
[6]   Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL [J].
Heinemeyer, T ;
Wingender, E ;
Reuter, I ;
Hermjakob, H ;
Kel, AE ;
Kel, OV ;
Ignatieva, EV ;
Ananko, EA ;
Podkolodnaya, OA ;
Kolpakov, FA ;
Podkolodny, NL ;
Kolchanov, NA .
NUCLEIC ACIDS RESEARCH, 1998, 26 (01) :362-367
[7]   Induction of hydroxyapatite resorptive activity in bone marrow cell populations resistant to bafilomycin A1 by a factor with restricted expression to bone and brain, neurochondrin [J].
Ishizuka, Y ;
Mochizuki, R ;
Yanai, K ;
Takatsuka, M ;
Nonomura, T ;
Niida, S ;
Horiguchi, H ;
Maeda, N ;
Fukamizu, A .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1999, 1450 (01) :92-98
[8]   GATA proteins identify a novel ventral interneuron subclass in the developing chick spinal cord [J].
Karunaratne, A ;
Hargrave, M ;
Poh, A ;
Yamada, T .
DEVELOPMENTAL BIOLOGY, 2002, 249 (01) :30-43
[9]   Phospholipase D1 and potential targets of its hydrolysis product, phosphatidic acid [J].
Ktistakis, NT ;
Delon, C ;
Manifava, M ;
Wood, E ;
Ganley, I ;
Sugars, JM .
BIOCHEMICAL SOCIETY TRANSACTIONS, 2003, 31 :94-97
[10]   Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system [J].
Lim, KC ;
Lakshmanan, G ;
Crawford, SE ;
Gu, Y ;
Grosveld, F ;
Engel, JD .
NATURE GENETICS, 2000, 25 (02) :209-212
12