Destruction of Schistosoma mansoni sporocysts in Biomphalaria glabrata after phytochemical exposure

被引：2

作者：

Friani, Gabriela ^{[1
,2
]}

Costa, Valdir A. ^{[3
]}

Mota, Ester ^{[4
]}

Faro, Marta Julia ^{[5
]}

Souza, Samaly ^{[6
]}

Figueiredo, Marcela ^{[7
]}

Golo, Patricia S. ^{[1
,8
]}

Mello-Silva, Clelia Christina ^{[2
]}

机构：

[1] Univ Fed Rural Rio de Janeiro, Inst Vet, Curso Posgrad Ciencias Vet, Rodovia BR 465,Km 07 S-N, BR-23890000 Seropedica, RJ, Brazil

[2] Fiocruz MS, Lab Avaliacao & Promocao Saude Ambiental, Inst Oswaldo Cruz, Av Brasil 4365, BR-21040360 Rio De Janeiro, RJ, Brazil

[3] Fiocruz MS, Lab Esquistossomose, Escola Nacl Saude Publ, Rua Leopoldo Bulhoes 1480, BR-21041210 Rio De Janeiro, RJ, Brazil

[4] Fiocruz MS, Lab Patol, Inst Oswaldo Cruz, Av Brasil 4365, BR-21040360 Rio De Janeiro, RJ, Brazil

[5] Fiocruz MS, Lab Biol & Parasitol Mamiferos Silvestres Reserva, Inst Oswaldo Cruz, Av Brasil 4365, BR-21040360 Rio De Janeiro, RJ, Brazil

[6] Ctr Dis Control & Prevent, 1600 Clifton Rd, Atlanta, GA 30329 USA

[7] Swansea Univ, Med Sch, Applies Mol Microbiol Grp, Singleton Pk, Swansea SA2 8PP, W Glam, Wales

[8] UFRRJ, Dept Parasitol Anim, Inst Vet, Rodovia BR 465,Km 07 S-N, BR-23890000 Seropedica, RJ, Brazil

来源：

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS | 2022年 / 94卷 / 02期

关键词：

Biomphalaria glabrata; Euphorbia milli; hemocytes; phytochemical; susceptibility; INTERMEDIATE HOST; HEMOCYTES; SNAILS;

D O I：

10.1590/0001-3765202220200620

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Schistosomiasis is a neglected tropical disease and affects over 200 million people worldwide. The snail Biomphalaria glabrata is one of the intermediate hosts of S. mansoni. The aim of this work was to verify the action of Euphorbia milii var. hislopii latex in the hemocytes profile and histopathology of B. glabrata infected by S. mansoni. Uninfected and infected snails were exposed to sublethal concentration of E. milli latex for 24 hours (1.0 mg/L). The survival rate was 88.5% for the uninfected snails and 66.6% for the infected and exposed snails. In the snails infected by S. mansoni, the exposure to E. milli latex promoted proliferation of hemocytes in the tentacles, mantle, digestive gland and kidney. In the digestive gland and the kidney, granulomatous reactions occurred around the sporocysts and caused their destruction. The number of circulating hemocytes from the group infected and exposed to E. milii latex was significantly higher than in the other groups. Three types of hemocytes were found: hyalinocytes, granulocytes and blast-like cells. We conclude that the E. milii latex influenced the cellular immune response of the susceptible B. glabrata strain to infection by S. mansoni, promoting the destruction of parasites.

引用

页数：10

共 37 条

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