Age-dependent decrease of retinal kynurenate and kynurenine aminotransferases in DBA/2J mice, a model of ocular hypertension

被引：13

作者：

Rejdak, R

Kohler, K

Kocki, T

Shenk, Y

Turski, WA

Okuno, E

Lehaci, C

Zagorski, Z

Zrenner, E

Schuettauf, F

机构：

[1] Univ Tubingen, Hosp Eye, Div Expt Ophthalmol, Dept Pathophysiol Vis & Neuroophthalmol, D-72076 Tubingen, Germany

[2] Med Univ Lublin, Tadeusz Krwawicz Chair Ophthalmol, PL-20079 Lublin, Poland

[3] Med Univ Lublin, Dept Pharmacol & Toxicol, PL-20069 Lublin, Poland

[4] Wakayama Med Univ, Dept Mol Med, Wakayama 6410012, Japan

[5] Tech Univ Timisoara, Hosp Eye, Dept Ophthalmol 2, RO-1900 Timisoara, Romania

来源：

VISION RESEARCH | 2004年 / 44卷 / 07期

关键词：

kynurenic acid; kynurenine aminotransferases; glaucoma; retinal degeneration; DBA/2J mice;

D O I：

10.1016/j.visres.2003.11.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The study examines age-dependent changes of kynurenic acid (KYNA) content and kynurenine aminotransferases (KAT I and KAT II) celluar expression in the retinas of DBA/2J mice. Retinas were obtained from DBA/2J mice of different ages (3, 6 and 11 months). C57BL6 mice were used as controls. As measured with HPLC, KYNA content decreased (p < 0.01) in the retinas of 6-month-old DBA/2J mice and continued to decrease (p < 0.0074) in the retinas of 11-month-old animals compared to the controls. Immunohistochemistry showed that expression of both KAT I and KAT II decreased markedly in the retinas of 11-month-old DBA/2J mice compared to controls. The impairment in KYNA biosynthesis in the retinas of DBA/2J mice may be one of the mechanisms of retinal neurodegeneration related to ocular hypertension. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：655 / 660

页数：6

共 25 条

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