Statins and transcriptional regulation: The FXR connection

被引：15

作者：

Habeos, I

Ziros, PG

Psyrogiannis, A

Vagenakis, AG

Papavassiliou, AG ^{[1
]}

机构：

[1] Univ Patras, Sch Med, Dept Biochem, GR-26110 Patras, Greece

[2] Univ Patras, Sch Med, Dept Internal Med, Patras 26500, Greece

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 334卷 / 02期

关键词：

farnesoid X receptor; simvastatin; gene expression; DNA binding; lipoprotein metabolism;

D O I：

10.1016/j.bbrc.2005.06.129

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Farnesoid X receptor (FXR) is a nuclear receptor involved in lipoprotein as well as glucose metabolism. Statins are widely used hypolipidemic agents with many pleiotropic actions. It is known that statins affect other nuclear hormone receptors, but no reports are available on the effect of these drugs on FXR. Employing an animal model (Syrian hamsters), we hereby present evidence to demonstrate that Simvastatin, a broadly prescribed statin, decreases the expression of FXR at both the RNA and protein levels and down-regulates its DNA-binding activity. This novel property may have important implications on the mode statins influence on lipoprotein and carbohydrate homeostasis in the organism. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：601 / 605

页数：5

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