Humans In Hypoxia: A Conspiracy Of Maladaptation?!

被引：78

作者：

Dempsey, Jerome A. ^{[1
,2
]}

Morgan, Barbara J. ^{[1
,3
]}

机构：

[1] Univ Wisconsin, Sch Med & Publ Hlth, John Rankin Lab Pulm Med, Madison, WI 53706 USA

[2] Univ Wisconsin, Sch Med & Publ Hlth, Dept Populat Hlth Sci, Madison, WI USA

[3] Univ Wisconsin, Dept Orthoped & Rehabil, Sch Med & Publ Hlth, Madison, WI USA

来源：

PHYSIOLOGY | 2015年 / 30卷 / 04期

基金：

美国国家卫生研究院;

关键词：

CHRONIC INTERMITTENT HYPOXIA; INDUCED ARTERIAL HYPOXEMIA; OBSTRUCTIVE SLEEP-APNEA; LASTING SYMPATHETIC ACTIVATION; LEFT-VENTRICULAR CONTRACTILITY; COUNTERPOINT HIGH-ALTITUDE; PERIPHERAL MUSCLE FATIGUE; BLOOD-PRESSURE; CAROTID-BODY; PULMONARY-HYPERTENSION;

D O I：

10.1152/physiol.00007.2015

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

We address adaptive vs. maladaptive responses to hypoxemia in healthy humans and hypoxic-tolerant species during wakefulness, sleep, and exercise. Types of hypoxemia discussed include short-term and life-long residence at high altitudes, the intermittent hypoxemia attending sleep apnea, or training regimens prescribed for endurance athletes. We propose that hypoxia presents an insult to O-2 transport, which is poorly tolerated in most humans because of the physiological cost.

引用

页码：304 / 316

页数：13

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