Humans In Hypoxia: A Conspiracy Of Maladaptation?!

被引：75
作者：
Dempsey, Jerome A. [1 ,2 ]
Morgan, Barbara J. [1 ,3 ]
机构：
[1] Univ Wisconsin, Sch Med & Publ Hlth, John Rankin Lab Pulm Med, Madison, WI 53706 USA
[2] Univ Wisconsin, Sch Med & Publ Hlth, Dept Populat Hlth Sci, Madison, WI USA
[3] Univ Wisconsin, Dept Orthoped & Rehabil, Sch Med & Publ Hlth, Madison, WI USA
来源：
PHYSIOLOGY | 2015年 / 30卷 / 04期
基金：
美国国家卫生研究院;
关键词：
CHRONIC INTERMITTENT HYPOXIA; INDUCED ARTERIAL HYPOXEMIA; OBSTRUCTIVE SLEEP-APNEA; LASTING SYMPATHETIC ACTIVATION; LEFT-VENTRICULAR CONTRACTILITY; COUNTERPOINT HIGH-ALTITUDE; PERIPHERAL MUSCLE FATIGUE; BLOOD-PRESSURE; CAROTID-BODY; PULMONARY-HYPERTENSION;
D O I：
10.1152/physiol.00007.2015
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
We address adaptive vs. maladaptive responses to hypoxemia in healthy humans and hypoxic-tolerant species during wakefulness, sleep, and exercise. Types of hypoxemia discussed include short-term and life-long residence at high altitudes, the intermittent hypoxemia attending sleep apnea, or training regimens prescribed for endurance athletes. We propose that hypoxia presents an insult to O-2 transport, which is poorly tolerated in most humans because of the physiological cost.
引用
收藏
页码：304 / 316
页数：13
相关论文
共 133 条
  • [1] Breathing and sleep at high altitude
    Ainslie, Philip N.
    Lucas, Samuel J. E.
    Burgess, Keith R.
    [J]. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 2013, 188 (03) : 233 - 256
  • [2] MECHANISM OF REDUCED CARDIAC STROKE VOLUME AT HIGH-ALTITUDE
    ALEXANDER, JK
    GROVER, RF
    [J]. CLINICAL CARDIOLOGY, 1983, 6 (06) : 301 - 303
  • [3] The polymorphic and contradictory aspects of intermittent hypoxia
    Almendros, Isaac
    Wang, Yang
    Gozal, David
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2014, 307 (02) : L129 - L140
  • [4] Inspiratory muscle work in acute hypoxia influences locomotor muscle fatigue and exercise performance of healthy humans
    Amann, Markus
    Pegelow, David F.
    Jacques, Anthony J.
    Dempsey, Jerome A.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2007, 293 (05) : R2036 - R2045
  • [5] Severity of arterial hypoxaemia affects the relative contributions of peripheral muscle fatigue to exercise performance in healthy humans
    Amann, Markus
    Romer, Lee M.
    Subudhi, Andrew W.
    Pegelow, David F.
    Dempsey, Jerome A.
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2007, 581 (01): : 389 - 403
  • [6] Opioid-mediated muscle afferents inhibit central motor drive and limit peripheral muscle fatigue development in humans
    Amann, Markus
    Proctor, Lester T.
    Sebranek, Joshua J.
    Pegelow, David F.
    Dempsey, Jerome A.
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2009, 587 (01): : 271 - 283
  • [7] TERMINAL PORTION OF PULMONARY ARTERIAL TREE IN PEOPLE NATIVE TO HIGH ALTITUDES
    ARIASSTELLA, J
    SALDANA, M
    [J]. CIRCULATION, 1963, 28 (05) : 915 - +
  • [8] Effect of altitude on the heart and the lungs
    Bártsch, Peter
    Simon, J.
    Gibbs, R.
    [J]. CIRCULATION, 2007, 116 (19) : 2191 - 2202
  • [9] Higher offspring survival among Tibetan women with high oxygen saturation genotypes residing at 4,000 m
    Beall, CM
    Song, KJ
    Elston, RC
    Goldstein, MC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (39) : 14300 - 14304
  • [10] Pulmonary nitric oxide in mountain dwellers
    Beall, CM
    Laskowski, D
    Strohl, KP
    Soria, R
    Villena, M
    Vargas, E
    Alarcon, AM
    Gonzales, C
    Erzurum, SC
    [J]. NATURE, 2001, 414 (6862) : 411 - 412
12345678910