Synthesis of Substituted Indenes through Iron-Catalyzed Annulation of Benzylic Alcohols with Alkynes

被引：43
作者：
Bu, Xiuli [1 ]
Hong, Jianquan [1 ]
Zhou, Xigeng [1 ,2 ]
机构：
[1] Fudan Univ, Dept Chem, Shanghai Key Lab Mol Catalysis & Innovat Mat, Shanghai 200433, Peoples R China
[2] State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2011年 / 353卷 / 11-12期
基金：
高等学校博士学科点专项科研基金;
关键词：
alkynes; annulation; benzylic alcohols; iron trichloride; polysubstituted indenes; H BOND ACTIVATION; FRIEDEL-CRAFTS ALKYLATION; ONE-STEP SYNTHESIS; C-C; REGIOSELECTIVE SYNTHESIS; PROPARGYLIC ALCOHOLS; EFFICIENT SYNTHESIS; ALLYLIC ALKYLATION; TANDEM REACTIONS; BENZYLATION;
D O I：
10.1002/adsc.201100065
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A convenient and efficient method for the synthesis of polysubstituted indenes has been developed by the iron(III) trichloride-catalyzed tandem mono- and dibenzylation/cyclization reactions of benzylic alcohols with alkynes. This method is featured with the easily available starting materials, cheap catalyst, simple manipulation and mild conditions.
引用
收藏
页码：2111 / 2118
页数：8
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