IgA nephropathy in children and in adults: two separate entities or the same disease?

被引:45
作者
Coppo, Rosanna [1 ]
Robert, Thomas [2 ]
机构
[1] Regina Margherita Hosp, Fdn Ric Molinette, Turin, Italy
[2] Ctr Nephrol & Transplantat Renale, AP HM, Marseille, France
关键词
IgA nephropathy; Children; Risk factors; Progression; GALACTOSE-DEFICIENT IGA1; REGULATORY T-CELLS; HENOCH-SCHONLEIN PURPURA; CHRONIC KIDNEY-DISEASE; OXFORD CLASSIFICATION; PEDIATRIC-PATIENTS; CONTROLLED-TRIAL; PREDNISONE THERAPY; DIETARY ANTIGENS; OXIDATIVE STRESS;
D O I
10.1007/s40620-020-00725-0
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
IgA nephropathy (IgAN) is observed in subjects of any age, however perspective and management of this disease are different between adult and pediatrician Nephrologists. Most children with IgAN present with gross hematuria rapidly vanishing or persistent mild microscopic hematuria, which rarely progresses to end stage renal disease (ESRD) over the pediatric observation. The perspective of IgAN in adults is of a slowly progressive glomerular disease with 30-40% probabilities to reach ESRD. However, mild cases of IgAN in children might be missed with manifestation of irreversible damage only decades after the true onset, as 50% of subjects with IgAN enter renal replacement treatment before the age of 50 years. In both adults and children the assessment of risk profile is crucial to avoid overtreatment in benign cases or institute a prompt and valid therapy in potentially progressive cases. In case of common risk factors, new therapeutic opportunities tested in adults might be applied to children with the expectation of similar results. If IgAN is the same disease in spite of different clinical profiles in children and adults, an early intervention may be the correct way to prevent progression decades later. On the contrary, if we are dealing with different clinical entities, the treatment in pediatric and in adult settings must be kept apart. This review addresses to report similarities and differences of IgAN across the life periods in order to reason on the application of newly offered treatments over the entire spectrum of this disease or in focused age indications.
引用
收藏
页码:1219 / 1229
页数:11
相关论文
共 50 条
[41]   TREATMENT OF IGA NEPHROPATHY IN CHILDREN - REPLY [J].
WALDO, FB .
PEDIATRIC NEPHROLOGY, 1994, 8 (03) :395-395
[42]   Steroid therapy in children with IgA nephropathy [J].
Alexandra Cambier ;
Olivia Boyer ;
Georges Deschenes ;
James Gleeson ;
Anne Couderc ;
Julien Hogan ;
Thomas Robert .
Pediatric Nephrology, 2020, 35 :359-366
[43]   Biologics and Non-Biologics Immunosuppressive Treatments for IgA Nephropathy in Both Adults and Children [J].
Chiarenza, Decimo Silvio ;
Verrina, Enrico Eugenio ;
La Porta, Edoardo ;
Caridi, Gianluca ;
Ghiggeri, Gian Marco ;
Mortari, Gabriele ;
Lugani, Francesca ;
Angeletti, Andrea ;
Bigatti, Carolina .
JOURNAL OF CLINICAL MEDICINE, 2024, 13 (09)
[44]   Validation of the children international IgA nephropathy prediction tool based on data in Southwest China [J].
Yu, Xixi ;
Li, Jiacheng ;
Tao, Chengrong ;
Jiao, Jia ;
Wan, Junli ;
Zhong, Cheng ;
Yang, Qin ;
Shi, Yongqi ;
Zhang, Gaofu ;
Yang, Haiping ;
Li, Qiu ;
Wang, Mo .
FRONTIERS IN PEDIATRICS, 2023, 11
[45]   IGA NEPHROPATHY AND HENOCH-SCHONLEIN PURPURE IN THE SAME FAMILY [J].
BRONSOMS, J ;
VALLES, M ;
MATE, G ;
MATAS, M ;
MAURI, J ;
BERNARDO, L ;
LIARTE, A .
NEFROLOGIA, 1995, 15 (02) :171-174
[46]   Dyslipidemia may be a risk factor for progression in children with IgA nephropathy [J].
Hongjie Zhuang ;
Zhilang Lin ;
Shuhan Zeng ;
Mengjie Jiang ;
Lizhi Chen ;
Xiaoyun Jiang ;
Yuanyuan Xu .
Pediatric Nephrology, 2022, 37 :3147-3156
[47]   Updating the International IgA Nephropathy Prediction Tool for use in children [J].
Barbour, Sean J. ;
Coppo, Rosanna ;
Er, Lee ;
Russo, Maria Luisa ;
Liu, Zhi-Hong ;
Ding, Jie ;
Katafuchi, Ritsuko ;
Yoshikawa, Norishige ;
Xu, Hong ;
Kagami, Shoji ;
Yuzawa, Yukio ;
Emma, Francesco ;
Cambier, Alexandra ;
Peruzzi, Licia ;
Wyatt, Robert J. ;
Cattran, Daniel C. .
KIDNEY INTERNATIONAL, 2021, 99 (06) :1439-1450
[48]   Clinical Characteristics of Concomitant Nephrotic IgA Nephropathy and Minimal Change Disease in Children [J].
Shen, Huijun ;
Gu, Weizhong ;
Mao, Jianhua ;
Zhu, Xiujuan ;
Jin, Xia ;
Fu, Haidong ;
Liu, Aimin ;
Shu, Qiang ;
Du, Lizhong .
NEPHRON, 2015, 130 (01) :21-28
[49]   A histologic classification of IgA nephropathy for predicting long-term prognosis: emphasis on end-stage renal disease [J].
Kawamura, Tetsuya ;
Joh, Kensuke ;
Okonogi, Hideo ;
Koike, Kentaro ;
Utsunomiya, Yasunori ;
Miyazaki, Yoichi ;
Matsushima, Masato ;
Yoshimura, Mitsuhiro ;
Horikoshi, Satoshi ;
Suzuki, Yusuke ;
Furusu, Akira ;
Yasuda, Takashi ;
Shirai, Sayuri ;
Shibata, Takanori ;
Endoh, Masayuki ;
Hattori, Motoshi ;
Akioka, Yuko ;
Katafuchi, Ritsuko ;
Hashiguchi, Akinori ;
Kimura, Kenjiro ;
Matsuo, Seiichi ;
Tomino, Yasuhiko .
JOURNAL OF NEPHROLOGY, 2013, 26 (02) :350-357
[50]   IgA nephropathy in children and adults: comparison of histologic features and clinical outcomes [J].
Haas, Mark ;
Rahman, M. Hafizur ;
Cohn, Richard A. ;
Fathallah-Shaykh, Sahar ;
Ansari, Adeel ;
Bartosh, Sharon M. .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2008, 23 (08) :2537-2545