Synthesis and antitubercular activity of new N,N-diaryl-4-(4,5-dichloroimidazole-2-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxamides

被引：0
|
作者：
Amini, M. [1 ]
Navidpour, L. [1 ]
Shafiee, A. [1 ]
机构：
[1] Univ Tehran Med Sci, Fac Pharm & Pharmaceut Sci, Res Ctr, Dept Med Chem, Tehran 14174, Iran
来源：
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES | 2008年 / 16卷 / 01期
关键词：
antituberculosis; dihydropyridine; dichloroimidazole;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background and the purpose of the study: Dihydropyridines having carboxamides in 3 and 5 positions show anti-tuberculosis activity. The purpose of the present study was to synthesize new DHPs having possible anti-tuberculosis activity. Methods: 4,5-Dichloroimidazole-2-carboxaldehyde was condensed with N-arylaceto-acetamides and ammonium acetate in methanol to give N,N-diaryl-4-(4,5-dichloroimidazole-2-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxamides. All compounds were screened for their antitubercular activity against Mycobacterium tuberculosis (H(37)Rv). Results and major conclusion: Some of the new synthesized compounds exhibited a moderate activity in comparison to rifampicin.
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页码：9 / 12
页数：4
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