Metal-Free Access to (E/Z)-α-Fluorovinyl Phosphorus Compounds from gem-Difluorostyrenes

被引：15

作者：

Peng, Yingyuan ^{[1
]}

Zhang, Xiaofei ^{[2
]}

Qi, Xueyu ^{[2
]}

He, Qian ^{[2
]}

Zhang, Bin ^{[1
]}

Hao, Jian ^{[1
]}

Yang, Chunhao ^{[2
]}

机构：

[1] Shanghai Univ, Dept Chem, Innovat Drug Res Ctr, Shangda Rd 99, Shanghai 200436, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Addition; gem-Difluorostyrene; Phosphorus; alpha-Fluorovinyl; Phosphine oxide; ALPHA-FLUORINATED PHOSPHONATES; CRAFTS-TYPE CYCLIZATION; CATALYZED HYDROPHOSPHORYLATION; DIFLUOROALKENES; ALKYNES; FLUOROALKENYLATION; ACTIVATION; ALKYLATION; EFFICIENT; GENERATE;

D O I：

10.1002/ejoc.201801602

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and efficient method for the synthesis of (E/Z)-alpha-fluorovinyl phosphorus compounds from gem-difluorostyrenes with diphenylphosphine oxide/dialkyl phosphate and DBU at room temperature was developed. A series of 1-fluorovinyl phosphine oxides/phosphonates were obtained with moderate to excellent yields in these reactions. Additionally, most isomers (E/Z type) of the target compounds could be easily separated and purified by column chromatography.

引用

页码：1170 / 1177

页数：8

共 17 条

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