Trashing the genome: The role of nucleases during apoptosis

被引：231

作者：

Samejima, K ^{[1
]}

Earnshaw, WC ^{[1
]}

机构：

[1] Univ Edinburgh, Inst Cell Biol, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 09期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nrm1715

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Two classes of nucleases degrade the cellular DNA during apoptosis. Cell-autonomous nucleases cleave DNA within the dying cell. They are not essential for apoptotic cell death or the life of the organism, but they might affect the efficiency of the process. By contrast, waste-management nucleases are essential for the life of the organism. In post-engulfment DNA degradation, the DNA of apoptotic cells is destroyed in lysosomes of the cells that have phagocytosed the corpses. Waste-management nucleases also destroy DNA that is released into the extracellular compartment. Here, we describe the complex group of nucleases that are involved in DNA destruction during apoptotic cell death.

引用

收藏

页码：677 / 688

页数：12

相关论文

共 142 条

[1] The yeast exosome and human PM-Scl are related complexes of 3′→5′ exonucleases [J].

Allmang, C ;

Petfalski, E ;

Podtelejnikov, A ;

Mann, M ;

Tollervey, D ;

Mitchell, P .

GENES & DEVELOPMENT, 1999, 13 (16) :2148-2158

[2] Degradation of ribosomal RNA precursors by the exosome [J].

Allmang, Christine ;

Mitchell, Philip ;

Petfalski, Elisabeth ;

Tollervey, David .

NUCLEIC ACIDS RESEARCH, 2000, 28 (08) :1684-1691

[3] L-DNase II activation by the 24 kDa apoptotic protease (AP24) in TNFα-induced apoptosis [J].

Altairac, V ;

Wright, SC ;

Courtois, Y ;

Torriglia, A .

CELL DEATH AND DIFFERENTIATION, 2003, 10 (09) :1109-1111

[4]

ANZAI N, 1995, BLOOD, V86, P917

[5] Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization [J].

Arnoult, D ;

Gaume, B ;

Karbowski, M ;

Sharpe, JC ;

Cecconi, F ;

Youle, RJ .

EMBO JOURNAL, 2003, 22 (17) :4385-4399

[6] Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli [J].

Arnoult, D ;

Parone, P ;

Martinou, JC ;

Antonsson, B ;

Estaquier, J ;

Ameisen, JC .

JOURNAL OF CELL BIOLOGY, 2002, 159 (06) :923-929

[7] On the evolutionary conservation of the cell death pathway:: Mitochondrial release of an apoptosis-inducing factor during Dictyostelium discoideum cell death [J].

Arnoult, D ;

Tatischeff, I ;

Estaquier, J ;

Girard, M ;

Sureau, F ;

Tissier, JP ;

Grodet, A ;

Dellinger, M ;

Traincard, F ;

Kahn, A ;

Ameisen, JC ;

Petit, PX .

MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (10) :3016-3030

[8]

BARRY MA, 1993, CANCER RES, V53, P2349

[9] Characterization of splice variants of human caspase-activated DNase with CIDE-N structure and function [J].

Bayascas, JR ;

Yuste, VJ ;

Solé, C ;

Sánchez-López, I ;

Segura, MF ;

Perera, R ;

Comella, JX .

FEBS LETTERS, 2004, 566 (1-3) :234-240

[10] Nuclear translocation of a leukocyte elastase inhibitor/elastase complex during staurosporine-induced apoptosis:: Role in the generation of nuclear L-DNase II activity [J].

Belmokhtar, CA ;

Torriglia, A ;

Counis, MF ;

Courtois, Y ;

Jacquemin-Sablon, A ;

Ségal-Bendirdjian, E .

EXPERIMENTAL CELL RESEARCH, 2000, 254 (01) :99-109

← 1 2 3 4 5 6 7 8 9 10 →