Vaccine-induced thrombotic thrombocytopenia following coronavirus vaccine: A narrative review

被引：14

作者：

Ahmed, Syed Hassan ^{[1
]}

Shaikh, Taha Gul ^{[1
]}

Waseem, Summaiyya ^{[1
]}

Qadir, Nashwa Abdul ^{[1
]}

Yousaf, Zohaib ^{[2
]}

Ullah, Irfan ^{[3
]}

机构：

[1] Dow Univ Hlth Sci, Karachi, Pakistan

[2] Hamad Med Corp, Dept Internal Med, Doha, Qatar

[3] Gandhara Univ, Kabir Med Coll, Peshawar, Pakistan

来源：

ANNALS OF MEDICINE AND SURGERY | 2022年 / 73卷

关键词：

COVID-19; vaccine; Vaccine induced thrombotic thrombocytopenia; Vaccine induced immune thrombotic thrombocytopenia; Thrombotic thrombocytopenia; VITT; PLATELET ACTIVATION; COVID-19; VACCINE; MOLECULAR MIMICRY; HEPARIN; COMPLEXES;

D O I：

10.1016/j.amsu.2021.102988

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The novel coronavirus pandemic has taken a toll on the global healthcare systems and economy. Safety precautions, along with vaccination, are the most effective preventive measures. The global vaccination program against COVID-19 has dramatically reduced the number of deaths and cases. However, the incidence of thrombotic events and thrombocytopenia post-COVID-19 vaccination known as vaccine-induced thrombotic thrombocytopenia has raised safety concerns. This has led to an element of vaccine hesitancy. The exact mechanism for vaccine-induced thrombotic thrombocytopenia is unknown. Although the incidence of thrombosis associated with COVID-19 vaccination is low, it still requires attention, especially in older people, smokers, and people with preexisting comorbidities. This study aims to review the pathophysiology, diagnosis, and management of vaccine-induced thrombotic thrombocytopenia, to provide a concise and comprehensive update.

引用

页数：10

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