Coronavirus Disease 2019 (COVID-19) Transmission in the United States Before Versus After Relaxation of Statewide Social Distancing Measures

被引:18
作者
Tsai, Alexander C. [1 ,2 ,3 ]
Harling, Guy [4 ,5 ]
Reynolds, Zahra [6 ]
Gilbert, Rebecca F. [6 ]
Siedner, Mark J. [1 ,3 ,5 ,6 ]
机构
[1] Massachusetts Gen Hosp, Ctr Global Hlth, Boston, MA USA
[2] Massachusetts Gen Hosp, Hlth Policy Res Ctr, Boston, MA USA
[3] Harvard Med Sch, Boston, MA 02115 USA
[4] UCL, London, England
[5] Africa Hlth Res Inst, Kwa Zulu, South Africa
[6] Massachusetts Gen Hosp, Med Practice Evaluat Ctr, Boston, MA USA
基金
美国国家卫生研究院;
关键词
COVID-19; SARS-CoV-2; basic reproductive number; public health regulations; social distancing;
D O I
10.1093/cid/ciaa1502
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. Weeks after issuing social distancing orders to suppress severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and reduce growth in cases of severe coronavirus disease 2019 (COVID-19), all US states and the District of Columbia partially or fully relaxed these measures. Methods. We identified all statewide social distancing measures that were implemented and/or relaxed in the United States between 10 March and 15 July 2020, triangulating data from state government and third-party sources. Using segmented linear regression, we estimated the extent to which relaxation of social distancing affected epidemic control, as indicated by the time-varying, state-specific effective reproduction number (R-t). Results. In the 8 weeks prior to relaxation, mean R-t declined by 0.012 units per day (95% confidence interval [CI], -.013 to -.012), and 46/51 jurisdictions achieved R-t < 1.0 by the date of relaxation. After relaxation of social distancing, R-t reversed course and began increasing by 0.007 units per day (95% CI,.006-.007), reaching a mean R-t of 1.16. Eight weeks later, the mean Rt was 1.16 and only 9/51 jurisdictions were maintaining an R-t < 1.0. Parallel models showed similar reversals in the growth of COVID-19 cases and deaths. Indicators often used to motivate relaxation at the time of relaxation (eg, test positivity rate <5%) predicted greater postrelaxation epidemic growth. Conclusions. We detected an immediate and significant reversal in SARS-CoV-2 epidemic suppression after relaxation of social distancing measures across the United States. Premature relaxation of social distancing measures undermined the country's ability to control the disease burden associated with COVID-19.
引用
收藏
页码:S120 / S126
页数:7
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