Lactobacillus acidophilus Suppresses Colitis-Associated Activation of the IL-23/Th17 Axis

被引：77

作者：

Chen, Linlin ^{[1
]}

Zou, Yiyou ^{[1
]}

Peng, Jie ^{[1
]}

Lu, Fanggen ^{[2
]}

Yin, Yani ^{[1
]}

Li, Fujun ^{[1
]}

Yang, Junwen ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Gastroenterol, Changsha 410011, Hunan, Peoples R China

[2] Cent South Univ, Xiangya Hosp 2, Dept Gastroenterol, Changsha 410008, Hunan, Peoples R China

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2015年 / 2015卷

关键词：

INFLAMMATORY-BOWEL-DISEASE; TH17; CELLS; T-CELLS; IL-17; INTERLEUKIN-17; EXPRESSION; ALPHA; BETA; HOMEOSTASIS; CYTOKINES;

D O I：

10.1155/2015/909514

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aim of this paper is to determine the modulatory effects of Lactobacillus acidophilus on the IL-23/Th17 immune axis in experimental colitis. DSS-induced mouse models of UC were to be saline, hormones, and different concentrations of Lactobacillus acidophilus intervention. The expression of interleukin-(IL-) 17, tumor necrosis factor alpha(TNF alpha), IL-23, transforming growth factor beta 1(TGF beta 1), signal transducer and activator of transcription 3 (STAT3), and phosphorylated (p)-STAT3 was examined by RT-PCR, Western blotting, and immunohistochemical analysis. And the results showed that administration of L. acidophilus suppressed Th17 cell-mediated secretion of proinflammatory cytokine IL-17 through downregulation of IL-23 and TGF beta 1 expression and downstream phosphorylation of p-STAT3.

引用

页数：10

共 35 条

[1] Lactobacillus casei and Lactobacillus acidophilus Regulate Inflammatory Pathway and Improve Antioxidant Status in Collagen-Induced Arthritic Rats [J].

Amdekar, Sarika ;

Singh, Vinod ;

Kumar, Avnish ;

Sharma, Poonam ;

Singh, Rambir .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2013, 33 (01) :1-8

[2] Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease [J].

Babyatsky, MW ;

Rossiter, G ;

Podolsky, DK .

GASTROENTEROLOGY, 1996, 110 (04) :975-984

[3]

Caruso R, 2020, NAT REV IMMUNOL, V20, P411, DOI [10.1038/s41577-019-0268-7, 10.4161/gmic.20228]

[4] Efficacy profiles for different concentrations of Lactobacillus acidophilus in experimental colitis [J].

Chen, Lin-Lin ;

Zou, Yi-You ;

Lu, Fang-Gen ;

Li, Fu-Jun ;

Lian, Guang-Hui .

WORLD JOURNAL OF GASTROENTEROLOGY, 2013, 19 (32) :5347-5356

[5] Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses [J].

Chen, Qian-Qian ;

Yan, Li ;

Wang, Chang-Zheng ;

Wang, Wei-Hua ;

Shi, Hui ;

Su, Bin-Bin ;

Zeng, Qing-Huan ;

Du, Hai-Tao ;

Wan, Jun .

WORLD JOURNAL OF GASTROENTEROLOGY, 2013, 19 (29) :4702-4717

[6] TGF-β1 production in inflammatory bowel disease:: differing production patterns in Crohn's disease and ulcerative colitis [J].

Del Zotto, B ;

Mumolo, G ;

Pronio, AM ;

Montesani, C ;

Tersigni, R ;

Boirivant, M .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2003, 134 (01) :120-126

[7] Crosstalk Between the Intestinal Microbiota and the Innate Immune System in Intestinal Homeostasis and Inflammatory Bowel Disease [J].

Dupaul-Chicoine, Jeremy ;

Dagenais, Maryse ;

Saleh, Maya .

INFLAMMATORY BOWEL DISEASES, 2013, 19 (10) :2227-2237

[8] Vidofludimus Inhibits Colonic Interleukin-17 and Improves Hapten-Induced Colitis in Rats by a Unique Dual Mode of Action [J].

Fitzpatrick, Leo R. ;

Small, Jeffrey S. ;

Doblhofer, Robert ;

Ammendola, Aldo .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2012, 342 (03) :850-860

[9] 4SC-101, a Novel Immunosuppressive Drug, Inhibits IL-17 and Attenuates Colitis in Two Murine Models of Inflammatory Bowel Disease [J].

Fitzpatrick, Leo R. ;

Deml, Ludwig ;

Hofmann, Claudia ;

Small, Jeffrey S. ;

Groeppel, Manfred ;

Hamm, Svetlana ;

Lemstra, Sylvia ;

Leban, Johann ;

Ammendola, Aldo .

INFLAMMATORY BOWEL DISEASES, 2010, 16 (10) :1763-1777

[10] T Cell-Derived IL-17 Mediates Epithelial Changes in the Airway and Drives Pulmonary Neutrophilia [J].

Fogli, Laura K. ;

Sundrud, Mark S. ;

Goel, Swati ;

Bajwa, Sofia ;

Jensen, Kari ;

Derudder, Emmanuel ;

Sun, Amy ;

Coffre, Maryaline ;

Uyttenhove, Catherine ;

Van Snick, Jacques ;

Schmidt-Supprian, Marc ;

Rao, Anjana ;

Grunig, Gabriele ;

Durbin, Joan ;

Casola, Stefano S. ;

Rajewsky, Klaus ;

Koralov, Sergei B. .

JOURNAL OF IMMUNOLOGY, 2013, 191 (06) :3100-3111

← 1 2 3 4 →