Four Independent Molecular Prion Protein Parameters for Discriminating New Cases of C, L, and H Bovine Spongiform Encephalopathy in Cattle

被引：11

作者：

Langeveld, Jan P. M. ^{[1
]}

Erkens, Jo H. F. ^{[1
]}

Rammel, Ines ^{[2
]}

Jacobs, Jorg G. ^{[1
]}

Davidse, Aart ^{[1
]}

van Zijderveld, Fred G. ^{[1
]}

Bossers, Alex ^{[1
]}

Schildorfer, Hermann ^{[2
]}

机构：

[1] Cent Vet Inst Wageningen UR, NL-8200 AB Lelystad, Netherlands

[2] Austrian Agcy Hlth & Food Safety, Inst Vet Dis Control, A-2340 Modling, Austria

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2011年 / 49卷 / 08期

关键词：

MONOCLONAL-ANTIBODIES; GREAT-BRITAIN; ATYPICAL BSE; IDENTIFICATION; SIMILARITIES; DISEASES; PRPSC; RICH;

D O I：

10.1128/JCM.01102-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In anticipation of the emergence of more variants of bovine spongiform encephalopathy (BSE), a semiquantitative display of the following four independent molecular diagnostic prion parameters was designed: N terminus, proteinase K (PK) resistance, glycoprofile, and mixed population. One H BSE case, three L BSE cases, six C BSE cases, and one unusual classical BSE (C BSE) case are reported.

引用

页码：3026 / 3028

页数：3

共 15 条

[11] Use of bovine recombinant prion protein and real-time quaking-induced conversion to detect cattle transmissible mink encephalopathy prions and discriminate classical and atypical L- and H-Type bovine spongiform encephalopathy
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PLOS ONE, 2017, 12 (02):
[12] Neuroanatomical Distribution of Disease-Associated Prion Protein in Cases of Bovine Spongiform Encephalopathy Detected by Fallen Stock Surveillance in Japan
Okada, Hiroyuki
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[13] Experimental H-type and L-type bovine spongiform encephalopathy in cattle: observation of two clinical syndromes and diagnostic challenges
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Bone, Gemma E.
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[14] Detection of Disease-Associated Prion Protein in the Posterior Portion of the Small Intestine Involving the Continuous Peyer's Patch in Cattle Orally Infected with Bovine Spongiform Encephalopathy Agent
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Iwamaru, Y.
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TRANSBOUNDARY AND EMERGING DISEASES, 2011, 58 (04) : 333 - 343
[15] Immunohistochemical Detection of Disease-Associated Prion Protein in the Intestine of Cattle Naturally Affected with Bovine Spongiform Encephalopathy by Using an Alkaline-Based Chemical Antigen Retrieval Method
Okada, Hiroyuki
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JOURNAL OF VETERINARY MEDICAL SCIENCE, 2010, 72 (11): : 1423 - 1429

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