A new indole derivative from the red alga Chondria atropurpurea.: Isolation, structure determination, and anthelmintic activity

被引：88
作者：
Davyt, D
Entz, W
Fernandez, R
Mariezcurrena, R
Mombrú, AW
Saldaña, J
Domínguez, L
Coll, J
Manta, E
机构：
[1] Univ Republ, Fac Quim, Catedra Quim Farmaceut, Montevideo 2124, Uruguay
[2] Univ Republ, Fac Quim, Catedra Cristalog, Montevideo 2124, Uruguay
[3] Univ Republ, Fac Quim, Catedra Farmacol, Montevideo 2124, Uruguay
[4] Univ Republ, Fac Quim, Catedra Bot, Montevideo 2124, Uruguay
来源：
JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 12期
关键词：
D O I：
10.1021/np980114c
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Chondriamide C (3), a new bis(indole) amide, was isolated from the red alga Chondria atropurpurea, and its structure was established from spectroscopic data and chemical transformations. A new natural product, S-indoleacrylamide (4), and the previously described chondriamides A and B (1, 2) and 3-indoleacrylic acid (5) were also isolated. The anthelmintic activities of compounds 1, 3, 4, and 6 (the O,N-1,N-1-trimethyl derivative of compound 2) against Nippostrongylus brasiliensis in vitro were evaluated.
引用
收藏
页码：1560 / 1563
页数：4
相关论文
共 18 条
  • [1] CHEMISTRY OF VERONGIDA SPONGES .3. CONSTITUENTS OF A CARIBBEAN VERONGULA SP
    CIMINIELLO, P
    FATTORUSSO, E
    MAGNO, S
    PANSINI, M
    [J]. JOURNAL OF NATURAL PRODUCTS-LLOYDIA, 1994, 57 (11): : 1564 - 1569
  • [2] Crews Phil, 1993, V1, P343
  • [3] New chromenols from the brown alga Desmarestia menziesii
    Davyt, D
    Enz, W
    Manta, E
    Navarro, G
    Norte, M
    [J]. NATURAL PRODUCT LETTERS, 1997, 9 (04): : 305 - 312
  • [4] Fattorusso E., 1980, MARINE NATURAL PRODU, VIII, P95
  • [5] FENICAL J, 1974, TETRAHEDRON LETT, V13, P1137
  • [6] Anthelmintic resistance in human helminths: Learning from the problems with worm control in livestock
    Geerts, S
    Coles, GC
    Gryseels, B
    [J]. PARASITOLOGY TODAY, 1997, 13 (04): : 149 - 151
  • [7] Gordon S, 1997, FARMACO, V52, P603
  • [8] New indole derivatives with free radical scavenging activity from Agrocybe cylindracea
    Kim, WG
    Lee, IK
    Kim, JP
    Ryoo, IJ
    Koshino, H
    Yoo, ID
    [J]. JOURNAL OF NATURAL PRODUCTS, 1997, 60 (07): : 721 - 723
  • [9] Alternatamides A-D: New bromotryptamine peptide antibiotics from the Atlantic marine bryozoan Amathia alternata
    Lee, NK
    Fenical, W
    Lindquist, N
    [J]. JOURNAL OF NATURAL PRODUCTS, 1997, 60 (07): : 697 - 699
  • [10] STRUCTURES OF DOMOILACTONE-A AND DOMOILACTONE-B, NOVEL AMINO-ACIDS FROM THE RED ALGA, CHONDRIA-ARMATA
    MAEDA, M
    KODAMA, T
    TANAKA, T
    YOSHIZUMI, H
    TAKEMOTO, T
    NOMOTO, K
    FUJITA, T
    [J]. TETRAHEDRON LETTERS, 1987, 28 (06) : 633 - 636
12