Synthesis and antimycobacterial activity of some benzyl- and methylisocyanurate derivatives

被引：2

作者：

Shulaeva, M. M. ^{[1
]}

Fattakhov, S. G. ^{[1
]}

Saifina, L. F. ^{[1
]}

Reznik, V. S. ^{[1
]}

Valijev, R. Sh. ^{[2
]}

Mingaleev, D. N. ^{[3
]}

机构：

[1] Russian Acad Sci, Kazan Sci Ctr, AE Arbuzov Inst Organ & Phys Chem, 8 Ul Akad Arbuzova, Kazan 420088, Russia

[2] Minist Healthcare Russian Federat, Kazan State Med Acad, Kazan 420012, Russia

[3] NE Bauman Kazan State Acad Vet Med, Kazan 420029, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2015年 / 64卷 / 09期

基金：

俄罗斯科学基金会;

关键词：

isocyanurate; sulfides; oxidation; sulfones; sulfoxides; amides; hydrazides; anti-mycobacterialactivity; MYCOBACTERIUM-BOVIS BCG; OXIDATION; SULFIDES;

D O I：

10.1007/s11172-015-1141-x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Alkylation of methyl thioglycolate with omega-(haloalkyl) derivatives of 1-benzyl-and 1-methylisocyanurates yielded 1,3-bis[omega-(methoxycarbonylmethylthio) alkyl)]-5-benzyl(methyl)-isocyanurates. Treatment of these compounds with ammonia or hydrazine hydrate and subsequent oxidation with hydrogen peroxide gives 1-benzyl- or 1-methylisocyanurates bearing two pharmacophoric substituents (i. e., carbamoyl, or carbazoylmethylsulfinyl, or sulfonyl groups) in the N-alkyl chains. The synthesized compounds exhibited antimycobacterial activity.

引用

页码：2215 / 2222

页数：8

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