Cell line-directed breast cancer research based on glucose metabolism status

被引：31
作者：
Farhadi, Pegah [1 ]
Yarani, Reza [2 ,3 ]
Valipour, Elahe [4 ]
Kiani, Sarah [1 ]
Hoseinkhani, Zohreh [1 ]
Mansouri, Kamran [1 ,5 ]
机构：
[1] Kermanshah Univ Med Sci, Med Biol Res Ctr, Hlth Technol Inst, Kermanshah, Iran
[2] Stanford Univ, Dept Radiol, Intervent Regenerat Med & Imaging Lab, Sch Med, Palo Alto, CA 94304 USA
[3] Herlev & Gentofte Hosp, Steno Diabet Ctr Copenhagen, Capital Reg Denmark Pediat, Copenhagen, Denmark
[4] Kermanshah Univ Med Sci, Med Technol Res Ctr, Hlth Technol Inst, Kermanshah, Iran
[5] Kermanshah Univ Med Sci, Sch Med, Dept Mol Med, Kermanshah, Iran
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2022年 / 146卷
关键词：
Breast cancer cell lines; Metabolism status; Glycolysis; Oxidative phosphorylation; PENTOSE-PHOSPHATE PATHWAY; FATTY-ACID OXIDATION; EXPRESSION ANALYSIS; RECEPTOR STATUS; MCF-7; DEHYDROGENASE; HETEROGENEITY; METABOLOMICS; SUBTYPES; SURVIVAL;
D O I：
10.1016/j.biopha.2021.112526
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Metabolic reprogramming is a potential hallmark of tumor cells to support continuous proliferation. Metabolic heterogeneity in breast cancer patients has been highlighted as the driving cause of tumor progression and resistance to anticancer drugs. Studying and identifying distinct metabolic alterations in breast cancer subtypes could offer new perspectives for faster diagnosis and treatment. Given cancer cell dependency on glycolysis, the primary energy source, this enzymatic pathway will play a critical role in targeting therapies. Knowledge about the specific metabolic dependencies of tumors for growth and proliferation can be promising for novel targeted and cell-based therapies. Here, the metabolic status with emphasis on glycolysis of breast cancer cell lines according to their classification was reviewed.
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页数：8
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