Discovery of Chromane-6-Sulfonamide Derivative as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist (vol 64, pg 16106, 2021)

被引:0
|
作者
Chen, Lei [1 ,2 ]
Su, Mei [3 ]
Wang, Wei [3 ]
Wang, Chun-Gu [1 ,2 ]
Assani, Israa [1 ,2 ]
Wang, Mu-Xuan [1 ,2 ]
Zhao, Shi-Feng [1 ,2 ]
Lv, Shen-Min [1 ,2 ]
Wang, Jia-Wei [1 ,2 ]
Sun, Bo [1 ,2 ]
Li, Yan [1 ,2 ]
Jin, Qiu [3 ]
Liao, Zhi-Xin [1 ,2 ]
机构
[1] Southeast Univ, Sch Chem & Chem Engn, Dept Pharmaceut Engn, Nanjing 211189, Peoples R China
[2] Southeast Univ, Jiangsu Prov Hitech Key Lab Biomed Res, Nanjing 211189, Peoples R China
[3] Jiangsu Carefree Pharmaceut Co Ltd, Nanjing 210042, Peoples R China
关键词
D O I
10.1021/acs.jmedchem.1c01926
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页数:1
相关论文
共 29 条
  • [1] Discovery of Chromane-6-Sulfonamide Derivative as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist (vol 64, pg 16106, 2021)
    Chen, Lei
    Su, Mei
    Wang, Wei
    Wang, Chun-Gu
    Assani, Israa
    Wang, Mu-Xuan
    Zhao, Shi-Feng
    Lv, Shen-Min
    Wang, Jia-Wei
    Sun, Bo
    Li, Yan
    Jin, Qiu
    Liao, Zhi-Xin
    JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (24) : 18235 - 18235
  • [2] Discovery of Chromane-6-Sulfonamide Derivative as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist
    Chen, Lei
    Su, Mei
    Jin, Qiu
    Wang, Wei
    Wang, Chun-Gu
    Assani, Israa
    Wang, Mu-Xuan
    Zhao, Shi-Feng
    Lv, Shen-Min
    Wang, Jia-Wei
    Sun, Bo
    Li, Yan
    Liao, Zhi-Xin
    JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (21) : 16106 - 16131
  • [3] Discovery of novel N-sulfonamide-tetrahydroisoquinolines as potent retinoic acid receptor-related orphan receptor γt agonists
    Ma, Xiaojun
    Sun, Nannan
    Li, Xinwei
    Fu, Wei
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 222
  • [4] Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists
    Lu, Lixue
    Chen, Song
    Yu, Mingcheng
    Zhou, Ronghui
    Guo, Siqi
    Chen, Ji-an
    Wang, Haojie
    Chen, Shijie
    Luo, Cheng
    Xie, Qiong
    Wang, Yonghui
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 256
  • [5] Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases
    Sun, Nannan
    Ma, Xiaojun
    Zhou, Kaifeng
    Zhu, Chen
    Cao, Zhonglian
    Wang, Yonghui
    Xu, Jun
    Fu, Wei
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 187
  • [6] Discovery of Novel N-Sulfonamide-tetrahydroquinolines as Potent Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists for the Treatment of Psoriasis
    Lv, Lunan
    Chen, Baiyu
    Gao, Yang
    Sun, Nannan
    Li, Wei
    Fu, Wei
    JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (23) : 21400 - 21420
  • [7] Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2
    von Berg, Stefan
    Xue, Yafeng
    Collins, Mia
    Llinas, Antonio
    Olsson, Roine I.
    Halvarsson, Torbjorn
    Lindskog, Maria
    Malmberg, Jesper
    Jirholt, Johan
    Krutrok, Nina
    Ramnegard, Marie
    Brannstrom, Marie
    Lundqvist, Anders
    Lepisto, Matti
    Aagaard, Anna
    McPheat, Jane
    Hansson, Eva L.
    Chen, Rongfeng
    Xiong, Yao
    Hansson, Thomas G.
    Narjes, Frank
    ACS MEDICINAL CHEMISTRY LETTERS, 2019, 10 (06): : 972 - 977
  • [8] AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2
    Narjes, Frank
    Llinas, Antonio
    von Berg, Stefan
    Jirholt, Johan
    Lever, Sarah
    Pehrson, Rikard
    Collins, Mia
    Malmberg, Anna
    Svanberg, Petter
    Xue, Yafeng
    Olsson, Roine, I
    Malmberg, Jesper
    Hughes, Glyn
    Hossain, Nafizal
    Grindebacke, Hanna
    Leffler, Agnes
    Krutrok, Nina
    Back, Elisabeth
    Ramnegard, Marie
    Lepisto, Matti
    Thunberg, Linda
    Aagaard, Anna
    McPheat, Jane
    Hansson, Eva L.
    Chen, Rongfeng
    Xiong, Yao
    Hansson, Thomas G.
    JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (18) : 13807 - 13829
  • [9] Discovery and Optimization of a Series of Sulfonamide Inverse Agonists for the Retinoic Acid Receptor-Related Orphan Receptor-α
    Doebelin, Christelle
    He, Yuanjun
    Campbell, Sean
    Nuhant, Philippe
    Kumar, Naresh
    Koenig, Marcel
    Garcia-Ordonez, Ruben
    Chang, Mi Ra
    Roush, William R.
    Lin, Li
    Kahn, Susan
    Cameron, Michael D.
    Griffin, Patrick R.
    Solt, Laura A.
    Kamenecka, Theodore M.
    MEDICINAL CHEMISTRY, 2019, 15 (06) : 676 - 684
  • [10] Discovery and evaluation of potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitors
    Sasaki, Yoshikazu
    Odan, Masahide
    Yamamoto, Shiho
    Kida, Shiro
    Ueyama, Azumi
    Shimizu, Masaya
    Haruna, Takayo
    Watanabe, Ayahisa
    Okuno, Takayuki
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 258