Stereoselective Total Synthesis of Paecilomycins E and F

被引：16
作者：
Bhunia, Nisith [1 ]
Das, Biswanath [1 ]
机构：
[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India
来源：
SYNTHESIS-STUTTGART | 2015年 / 47卷 / 10期
关键词：
resorcylic acid lactones; paecilomycin E; paecilomycin F; total synthesis; cis-butene-1; 4-diol; RESORCYLIC ACID LACTONES; ASYMMETRIC TOTAL-SYNTHESIS; AIGIALOMYCIN-D; GIBBERELLA-ZEAE; NATURAL-PRODUCTS; APICULAREN-A; FUNGUS; HSP90; INHIBITION; MACROLIDES;
D O I：
10.1055/s-0034-1380400
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The stereoselective total synthesis of two bioactive resorcylic acid lactones, paecilomycins E and F has been accomplished thorough a general pathway using cis-butene-1,4-diol as the starting material. The pivotal steps of the synthesis include Sharpless asymmetric epoxidation, Bestmann-Ohira alkynation, Jacobsen kinetic resolution, and Heck coupling reaction.
引用
收藏
页码：1499 / 1509
页数：11
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