Stereoselective Total Synthesis of Paecilomycins E and F

被引：16

作者：

Bhunia, Nisith ^{[1
]}

Das, Biswanath ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 10期

关键词：

resorcylic acid lactones; paecilomycin E; paecilomycin F; total synthesis; cis-butene-1; 4-diol; RESORCYLIC ACID LACTONES; ASYMMETRIC TOTAL-SYNTHESIS; AIGIALOMYCIN-D; GIBBERELLA-ZEAE; NATURAL-PRODUCTS; APICULAREN-A; FUNGUS; HSP90; INHIBITION; MACROLIDES;

D O I：

10.1055/s-0034-1380400

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereoselective total synthesis of two bioactive resorcylic acid lactones, paecilomycins E and F has been accomplished thorough a general pathway using cis-butene-1,4-diol as the starting material. The pivotal steps of the synthesis include Sharpless asymmetric epoxidation, Bestmann-Ohira alkynation, Jacobsen kinetic resolution, and Heck coupling reaction.

引用

页码：1499 / 1509

页数：11

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