Assessment of putative protein targets derived from the SARS genome

被引：15

作者：

Yan, L ^{[1
]}

Velikanov, M ^{[1
]}

Flook, P ^{[1
]}

Zheng, WJ ^{[1
]}

Szalma, S ^{[1
]}

Kahn, S ^{[1
]}

机构：

[1] Accelrys Inc, San Diego, CA 92121 USA

来源：

FEBS LETTERS | 2003年 / 554卷 / 03期

关键词：

severe acute respiratory syndrome genome; GeneAtlas pipeline; protein structure prediction; protein function annotation; high-throughput pipeline; homology modeling;

D O I：

10.1016/S0014-5793(03)01115-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability to rapidly and reliably develop hypotheses on the function of newly discovered protein sequences requires systematic and comprehensive analysis. Such an analysis, embodied within the DS GeneAtlas(TM) pipeline, has been used to critically evaluate the severe acute respiratory syndrome (SARS) genome with the goal of identifying new potential targets for viral therapeutic intervention. This paper discusses several new functional hypotheses on the roles played by the constituent gene products of SARS, and will serve as an example of how such assignments can be developed or extended on other systems of interest. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：257 / 263

页数：7

共 21 条

[1]

*ACC INC, 2002, TRANSM US MAN

[2] Coronavirus main proteinase (3CLpro) structure:: Basis for design of anti-SARS drugs [J].